Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice

Mathias Hohl, Manuel Mayr, Lisa Lang, Alexander G. Nickel, Javier Barallobre-Barreiro, Xiaoke Yin, Thimoteus Speer, Simina-Ramona Selejan, Claudia Goettsch, Katharina Erb, Claudia Fecher-Trost, Jan-Christian Reil, Benedikt Linz, Sven Ruf, Thomas Huebschle, Christoph Maack, Michael Boehm, Thorsten Sadowski, Dominik Linz*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)12605-12617
Number of pages13
JournalJournal of Biological Chemistry
Volume295
Issue number36
DOIs
Publication statusPublished - 4 Sep 2020

Keywords

  • cathepsin A
  • carboxypeptidase
  • extracellular matrix protein
  • oxidative stress
  • extracellular superoxide dismutase
  • cardiac hypertrophy
  • cardiac remodeling
  • left ventricular dysfunction
  • heart disease
  • secretome
  • superoxide dismutase (SOD)
  • oxygen radicals
  • heart failure
  • fibrosis
  • EC-SOD
  • OXIDATIVE STRESS
  • HEART
  • HYPERTROPHY
  • PROTECTS
  • COLLAGEN
  • MATRIX
  • REPAIR

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