Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

INIS

• mutations 100%
• lymphomas 100%
• neoplasms 100%
• mutants 87%
• transformations 62%
• solutions 50%
• substrates 50%
• rings 50%
• tyrosine 25%
• proteins 25%
• kinases 25%
• interactions 25%
• flexibility 12%
• perturbations 12%
• mice 12%
• phosphorylation 12%
• mimic 12%
• affinity 12%
• point mutations 12%
• surfaces 12%
• residues 12%
• resonance 12%
• ligases 12%
• x-ray diffraction 12%
• plasmons 12%

Keyphrases

• Helix 100%
• Myeloproliferative Neoplasms 100%
• Casitas B-lineage Lymphoma 100%
• Linker 100%
• Substrate-binding Domain 50%
• Conformation in Solution 37%
• RING Domain 37%
• Tyrosine Kinase 25%
• C-Cbl 25%
• Transformation Potential 25%
• Domain-domain Interaction 25%
• Phosphorylation 12%
• Ubiquitin 12%
• Point mutation 12%
• Chemical Nature 12%
• Ubiquitination 12%
• Negatively Regulate 12%
• Focus Formation 12%
• Extended Conformation 12%
• Small-angle X-ray Scattering 12%
• Ubiquitin Ligase 12%
• Oncogenic Potential 12%
• Surface Plasmon Resonance 12%
• Native State 12%
• Conserved Residues 12%
• Tyrosine Kinase Signaling 12%
• Mutational Hotspots 12%
• Domain Perturbation 12%
• Binding Affinity 12%

Biochemistry, Genetics and Molecular Biology

• Conformation 100%
• Solution and Solubility 80%
• Binding Domain 60%
• RING Finger Domain 60%
• Receptor Tyrosine Kinase 40%
• Point Mutation 20%
• Ubiquitin 20%
• Ubiquitination 20%
• X Ray 20%
• Binding Affinity 20%
• Surface Plasmon Resonance 20%
• Ubiquitin Ligase 20%