Case series of three adult patients with exceptional clinical presentations of haemophagocytic lymphohistiocytosis

M. Khairoun; F. Meynen; W. Vercoutere; H. L. Leavis

Case series of three adult patients with exceptional clinical presentations of haemophagocytic lymphohistiocytosis

M. Khairoun
, F. Meynen
, W. Vercoutere
, H. L. Leavis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Macrophage activation syndrome (MAS) is a secondary form of haemophagocytic lymphohistiocytosis (HLH). MAS-HLH is an underrecognised and life-threatening condition associated with a heterogeneous group of diseases including connective tissue disease and inflammatory disorders. Here, we report three cases of adult patients with MAS-HLH triggered by different entities, including systemic lupus erythematosus, Griscelli syndrome type 2, and Adult onset Still’s disease.

Original language	English
Pages (from-to)	136-141
Number of pages	6
Journal	Netherlands Journal of Medicine
Volume	78
Issue number	3
Publication status	Published - 1 Apr 2020

Keywords

Adults Still's disease
Griscelli syndrome type 2
haemophagocytic lymphohistiocytosis
macrophage activation syndrome
systemic lupus erythematosus
MACROPHAGE ACTIVATION SYNDROME
SYSTEMIC-LUPUS-ERYTHEMATOSUS
COMBINED IMMUNODEFICIENCY
REVERSION
DISEASE
MUTATION

Cite this

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title = "Case series of three adult patients with exceptional clinical presentations of haemophagocytic lymphohistiocytosis",

abstract = "Macrophage activation syndrome (MAS) is a secondary form of haemophagocytic lymphohistiocytosis (HLH). MAS-HLH is an underrecognised and life-threatening condition associated with a heterogeneous group of diseases including connective tissue disease and inflammatory disorders. Here, we report three cases of adult patients with MAS-HLH triggered by different entities, including systemic lupus erythematosus, Griscelli syndrome type 2, and Adult onset Still{\textquoteright}s disease.",

keywords = "Adults Still's disease, Griscelli syndrome type 2, haemophagocytic lymphohistiocytosis, macrophage activation syndrome, systemic lupus erythematosus, MACROPHAGE ACTIVATION SYNDROME, SYSTEMIC-LUPUS-ERYTHEMATOSUS, COMBINED IMMUNODEFICIENCY, REVERSION, DISEASE, MUTATION",

author = "M. Khairoun and F. Meynen and W. Vercoutere and Leavis, \{H. L.\}",

year = "2020",

month = apr,

day = "1",

language = "English",

volume = "78",

pages = "136--141",

journal = "Netherlands Journal of Medicine",

issn = "0300-2977",

publisher = "Van Zuiden Communications BV",

number = "3",

}

TY - JOUR

T1 - Case series of three adult patients with exceptional clinical presentations of haemophagocytic lymphohistiocytosis

AU - Khairoun, M.

AU - Meynen, F.

AU - Vercoutere, W.

AU - Leavis, H. L.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Macrophage activation syndrome (MAS) is a secondary form of haemophagocytic lymphohistiocytosis (HLH). MAS-HLH is an underrecognised and life-threatening condition associated with a heterogeneous group of diseases including connective tissue disease and inflammatory disorders. Here, we report three cases of adult patients with MAS-HLH triggered by different entities, including systemic lupus erythematosus, Griscelli syndrome type 2, and Adult onset Still’s disease.

AB - Macrophage activation syndrome (MAS) is a secondary form of haemophagocytic lymphohistiocytosis (HLH). MAS-HLH is an underrecognised and life-threatening condition associated with a heterogeneous group of diseases including connective tissue disease and inflammatory disorders. Here, we report three cases of adult patients with MAS-HLH triggered by different entities, including systemic lupus erythematosus, Griscelli syndrome type 2, and Adult onset Still’s disease.

KW - Adults Still's disease

KW - Griscelli syndrome type 2

KW - haemophagocytic lymphohistiocytosis

KW - macrophage activation syndrome

KW - systemic lupus erythematosus

KW - MACROPHAGE ACTIVATION SYNDROME

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - COMBINED IMMUNODEFICIENCY

KW - REVERSION

KW - DISEASE

KW - MUTATION

M3 - Article

SN - 0300-2977

VL - 78

SP - 136

EP - 141

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 3

ER -

Case series of three adult patients with exceptional clinical presentations of haemophagocytic lymphohistiocytosis

Abstract

Keywords

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