Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

Ozgur M. Koc*, Jan Damoiseaux, Inge H. M. van Loo, Heloise I. L. Masquillier, Astrid M. L. Oude Lashof

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)


We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination. (C) 2019 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)112-114
Number of pages3
Issue number2
Publication statusPublished - 10 Jan 2020


  • Hepatitis B
  • Vaccine
  • Non-responder
  • Humoral Immunity
  • Delayed seroprotection

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