Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

Ozgur M. Koc; Jan Damoiseaux; Inge H. M. van Loo; Heloise I. L. Masquillier; Astrid M. L. Oude Lashof

doi:10.1016/j.vaccine.2019.10.022

Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

Ozgur M. Koc^*, Jan Damoiseaux, Inge H. M. van Loo, Heloise I. L. Masquillier, Astrid M. L. Oude Lashof

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination. (C) 2019 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	112-114
Number of pages	3
Journal	Vaccine
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.vaccine.2019.10.022
Publication status	Published - 10 Jan 2020

Keywords

Hepatitis B
Vaccine
Non-responder
Humoral Immunity
Delayed seroprotection
IMMUNOGENICITY
EFFICACY

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10.1016/j.vaccine.2019.10.022Licence: CC BY-NC-ND

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title = "Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination",

abstract = "We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination. (C) 2019 Elsevier Ltd. All rights reserved.",

keywords = "Hepatitis B, Vaccine, Non-responder, Humoral Immunity, Delayed seroprotection, IMMUNOGENICITY, EFFICACY",

author = "Koc, {Ozgur M.} and Jan Damoiseaux and {van Loo}, {Inge H. M.} and Masquillier, {Heloise I. L.} and Lashof, {Astrid M. L. Oude}",

note = "Funding Information: {\"O}zg{\"u}r M Koc has received research grants and travel grants from Gilead to attend scientific Congresses. All payments were invoiced by Hasselt University and were all outside the submitted work. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = jan,

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doi = "10.1016/j.vaccine.2019.10.022",

language = "English",

volume = "38",

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journal = "Vaccine",

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T1 - Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

AU - Koc, Ozgur M.

AU - Damoiseaux, Jan

AU - van Loo, Inge H. M.

AU - Masquillier, Heloise I. L.

AU - Lashof, Astrid M. L. Oude

N1 - Funding Information: Özgür M Koc has received research grants and travel grants from Gilead to attend scientific Congresses. All payments were invoiced by Hasselt University and were all outside the submitted work. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2020/1/10

Y1 - 2020/1/10

N2 - We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination. (C) 2019 Elsevier Ltd. All rights reserved.

AB - We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination. (C) 2019 Elsevier Ltd. All rights reserved.

KW - Hepatitis B

KW - Vaccine

KW - Non-responder

KW - Humoral Immunity

KW - Delayed seroprotection

KW - IMMUNOGENICITY

KW - EFFICACY

U2 - 10.1016/j.vaccine.2019.10.022

DO - 10.1016/j.vaccine.2019.10.022

M3 - Article

C2 - 31648909

SN - 0264-410X

VL - 38

SP - 112

EP - 114

JO - Vaccine

JF - Vaccine

IS - 2

ER -

Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

Abstract

Keywords

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