TY - JOUR
T1 - Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies
AU - Zhang, Xuehong
AU - Spiegelman, Donna
AU - Baglietto, Laura
AU - Bernstein, Leslie
AU - Boggs, Deborah A.
AU - van den Brandt, Piet A.
AU - Buring, Julie E.
AU - Gapstur, Susan M.
AU - Giles, Graham G.
AU - Giovannucci, Edward
AU - Goodman, Gary
AU - Hankinson, Susan E.
AU - Helzlsouer, Kathy J.
AU - Horn-Ross, Pamela L.
AU - Inoue, Manami
AU - Jung, Seungyoun
AU - Khudyakov, Polyna
AU - Larsson, Susanna C.
AU - Lof, Marie
AU - McCullough, Marjorie L.
AU - Miller, Anthony B.
AU - Neuhouser, Marian L.
AU - Palmer, Julie R.
AU - Park, Yikyung
AU - Robien, Kim
AU - Rohan, Thomas E.
AU - Ross, Julie A.
AU - Schouten, Leo J.
AU - Shikany, James M.
AU - Tsugane, Shoichiro
AU - Visvanathan, Kala
AU - Weiderpass, Elisabete
AU - Wolk, Alicja
AU - Willett, Walter C.
AU - Zhang, Shumin M.
AU - Ziegler, Regina G.
AU - Smith-Warner, Stephanie A.
PY - 2012/3
Y1 - 2012/3
N2 - Background: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. Objective: We investigated these associations in a pooled analysis of 18 cohort studies. Design: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. Results: alpha-Carotene, beta-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): alpha-carotene (0.87; 95% CI: 0.78, 0.97), beta-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): a-carotene (1.04; 95% CI: 0.99, 1.09), beta-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for beta-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend
AB - Background: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. Objective: We investigated these associations in a pooled analysis of 18 cohort studies. Design: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. Results: alpha-Carotene, beta-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): alpha-carotene (0.87; 95% CI: 0.78, 0.97), beta-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): a-carotene (1.04; 95% CI: 0.99, 1.09), beta-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for beta-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend
U2 - 10.3945/ajcn.111.014415
DO - 10.3945/ajcn.111.014415
M3 - Article
C2 - 22277553
SN - 0002-9165
VL - 95
SP - 713
EP - 725
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 3
ER -