Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Yvonne M. H. Bruls; Marlies de Ligt; Lucas Lindeboom; Esther Phielix; Bas Havekes; Gert Schaart; Esther Kornips; Joachim E. Wildberger; Matthijs K. C. Hesselink; Deborah Muoio; Patrick Schrauwen; Vera B. Schrauwen-Hinderling

doi:10.1016/j.ebiom.2019.10.017

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Yvonne M. H. Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E. Wildberger, Matthijs K. C. Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B. Schrauwen-Hinderling^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	318-330
Number of pages	13
Journal	EBioMedicine
Volume	49
DOIs	https://doi.org/10.1016/j.ebiom.2019.10.017
Publication status	Published - Nov 2019

Keywords

L-carnitine
Metabolic flexibility
Insulin sensitivity
Acetylcarnitine
Impaired glucose tolerance
Hyperinsulinemic-euglycemic clamp
HYPERINSULINEMIC-EUGLYCEMIC CLAMP
INSULIN SENSITIVITY
FUEL METABOLISM
RESISTANCE
PLASMA
QUANTIFICATION
DISPOSAL
PROFILE
DIET
COA

Access to Document

10.1016/j.ebiom.2019.10.017

Cite this

Bruls, Y. M. H., de Ligt, M., Lindeboom, L., Phielix, E., Havekes, B., Schaart, G., Kornips, E., Wildberger, J. E., Hesselink, M. K. C., Muoio, D., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2019). Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. EBioMedicine, 49, 318-330. https://doi.org/10.1016/j.ebiom.2019.10.017

Bruls, Yvonne M. H. ; de Ligt, Marlies ; Lindeboom, Lucas ; Phielix, Esther ; Havekes, Bas ; Schaart, Gert ; Kornips, Esther ; Wildberger, Joachim E. ; Hesselink, Matthijs K. C. ; Muoio, Deborah ; Schrauwen, Patrick ; Schrauwen-Hinderling, Vera B. / Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance : A randomised controlled trial. In: EBioMedicine. 2019 ; Vol. 49. pp. 318-330.

@article{c2f01b82c1074fbfba0434e8af45e36f,

title = "Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial",

keywords = "L-carnitine, Metabolic flexibility, Insulin sensitivity, Acetylcarnitine, Impaired glucose tolerance, Hyperinsulinemic-euglycemic clamp, HYPERINSULINEMIC-EUGLYCEMIC CLAMP, INSULIN SENSITIVITY, FUEL METABOLISM, RESISTANCE, PLASMA, QUANTIFICATION, DISPOSAL, PROFILE, DIET, COA",

author = "Bruls, {Yvonne M. H.} and {de Ligt}, Marlies and Lucas Lindeboom and Esther Phielix and Bas Havekes and Gert Schaart and Esther Kornips and Wildberger, {Joachim E.} and Hesselink, {Matthijs K. C.} and Deborah Muoio and Patrick Schrauwen and Schrauwen-Hinderling, {Vera B.}",

year = "2019",

month = nov,

doi = "10.1016/j.ebiom.2019.10.017",

language = "English",

volume = "49",

pages = "318--330",

journal = "EBioMedicine",

issn = "2352-3964",

publisher = "Elsevier",

}

Bruls, YMH , de Ligt, M, Lindeboom, L, Phielix, E , Havekes, B , Schaart, G , Kornips, E , Wildberger, JE , Hesselink, MKC, Muoio, D, Schrauwen, P & Schrauwen-Hinderling, VB 2019, 'Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial', EBioMedicine, vol. 49, pp. 318-330. https://doi.org/10.1016/j.ebiom.2019.10.017

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance : A randomised controlled trial. / Bruls, Yvonne M. H.; de Ligt, Marlies; Lindeboom, Lucas; Phielix, Esther ; Havekes, Bas ; Schaart, Gert ; Kornips, Esther ; Wildberger, Joachim E.; Hesselink, Matthijs K. C.; Muoio, Deborah; Schrauwen, Patrick ; Schrauwen-Hinderling, Vera B.

In: EBioMedicine, Vol. 49, 11.2019, p. 318-330.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance

T2 - A randomised controlled trial

AU - Bruls, Yvonne M. H.

AU - de Ligt, Marlies

AU - Lindeboom, Lucas

AU - Phielix, Esther

AU - Havekes, Bas

AU - Schaart, Gert

AU - Kornips, Esther

AU - Wildberger, Joachim E.

AU - Hesselink, Matthijs K. C.

AU - Muoio, Deborah

AU - Schrauwen, Patrick

AU - Schrauwen-Hinderling, Vera B.

PY - 2019/11

Y1 - 2019/11

KW - L-carnitine

KW - Metabolic flexibility

KW - Insulin sensitivity

KW - Acetylcarnitine

KW - Impaired glucose tolerance

KW - Hyperinsulinemic-euglycemic clamp

KW - HYPERINSULINEMIC-EUGLYCEMIC CLAMP

KW - INSULIN SENSITIVITY

KW - FUEL METABOLISM

KW - RESISTANCE

KW - PLASMA

KW - QUANTIFICATION

KW - DISPOSAL

KW - PROFILE

KW - DIET

KW - COA

U2 - 10.1016/j.ebiom.2019.10.017

DO - 10.1016/j.ebiom.2019.10.017

M3 - Article

C2 - 31676389

VL - 49

SP - 318

EP - 330

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

ER -