Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Kei Asayama; Takayoshi Ohkubo; Hirohito Metoki; Taku Obara; Ryusuke Inoue; Masahiro Kikuya; Lutgarde Thijs; Jan A. Staessen; Yutaka Imai

doi:10.1038/hr.2012.125

Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Kei Asayama, Takayoshi Ohkubo, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Masahiro Kikuya, Lutgarde Thijs, Jan A. Staessen, Yutaka Imai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Hypertension guidelines recommend blood pressure self-measurement at home (HBP), but no previous trial has assessed cardiovascular outcomes in hypertensive patients treated according to HBP. The multicenter Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP; 2001-2010) trial involved 3518 patients (50% women; mean age 59.6 years) with an untreated systolic/diastolic HBP of 135-179/85-119 mm Hg. In a 2 x 3 design, patients were randomized to usual control (125-134/80-84 mm Hg (UC)) vs. tight control (= 0.13) in the three drug groups. In all patients combined, the risk of the primary end point independently increased by 41% (6-89%; P = 0.019) and 47% (15-87%; P = 0.0020) for a 1-s.d. increase in baseline (12.5 mm Hg) and follow-up (13.2 mm Hg) systolic HBP. The 5-year risk was minimal (

Original language	English
Pages (from-to)	1102-1110
Journal	Hypertension Research
Volume	35
Issue number	11
DOIs	https://doi.org/10.1038/hr.2012.125
Publication status	Published - Nov 2012

Keywords

antihypertensive drug treatment
blood pressure control
home blood pressure
randomized clinical trial

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10.1038/hr.2012.125

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title = "Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure",

abstract = "Hypertension guidelines recommend blood pressure self-measurement at home (HBP), but no previous trial has assessed cardiovascular outcomes in hypertensive patients treated according to HBP. The multicenter Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP; 2001-2010) trial involved 3518 patients (50% women; mean age 59.6 years) with an untreated systolic/diastolic HBP of 135-179/85-119 mm Hg. In a 2 x 3 design, patients were randomized to usual control (125-134/80-84 mm Hg (UC)) vs. tight control (= 0.13) in the three drug groups. In all patients combined, the risk of the primary end point independently increased by 41% (6-89%; P = 0.019) and 47% (15-87%; P = 0.0020) for a 1-s.d. increase in baseline (12.5 mm Hg) and follow-up (13.2 mm Hg) systolic HBP. The 5-year risk was minimal (",

keywords = "antihypertensive drug treatment, blood pressure control, home blood pressure, randomized clinical trial",

author = "Kei Asayama and Takayoshi Ohkubo and Hirohito Metoki and Taku Obara and Ryusuke Inoue and Masahiro Kikuya and Lutgarde Thijs and Staessen, {Jan A.} and Yutaka Imai",

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AU - Asayama, Kei

AU - Ohkubo, Takayoshi

AU - Metoki, Hirohito

AU - Obara, Taku

AU - Inoue, Ryusuke

AU - Kikuya, Masahiro

AU - Thijs, Lutgarde

AU - Staessen, Jan A.

AU - Imai, Yutaka

PY - 2012/11

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N2 - Hypertension guidelines recommend blood pressure self-measurement at home (HBP), but no previous trial has assessed cardiovascular outcomes in hypertensive patients treated according to HBP. The multicenter Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP; 2001-2010) trial involved 3518 patients (50% women; mean age 59.6 years) with an untreated systolic/diastolic HBP of 135-179/85-119 mm Hg. In a 2 x 3 design, patients were randomized to usual control (125-134/80-84 mm Hg (UC)) vs. tight control (= 0.13) in the three drug groups. In all patients combined, the risk of the primary end point independently increased by 41% (6-89%; P = 0.019) and 47% (15-87%; P = 0.0020) for a 1-s.d. increase in baseline (12.5 mm Hg) and follow-up (13.2 mm Hg) systolic HBP. The 5-year risk was minimal (

AB - Hypertension guidelines recommend blood pressure self-measurement at home (HBP), but no previous trial has assessed cardiovascular outcomes in hypertensive patients treated according to HBP. The multicenter Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP; 2001-2010) trial involved 3518 patients (50% women; mean age 59.6 years) with an untreated systolic/diastolic HBP of 135-179/85-119 mm Hg. In a 2 x 3 design, patients were randomized to usual control (125-134/80-84 mm Hg (UC)) vs. tight control (= 0.13) in the three drug groups. In all patients combined, the risk of the primary end point independently increased by 41% (6-89%; P = 0.019) and 47% (15-87%; P = 0.0020) for a 1-s.d. increase in baseline (12.5 mm Hg) and follow-up (13.2 mm Hg) systolic HBP. The 5-year risk was minimal (

KW - antihypertensive drug treatment

KW - blood pressure control

KW - home blood pressure

KW - randomized clinical trial

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DO - 10.1038/hr.2012.125

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SN - 0916-9636

VL - 35

SP - 1102

EP - 1110

JO - Hypertension Research

JF - Hypertension Research

IS - 11

ER -

Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

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Keywords

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