Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

Rachel E Climie; Muriel Tafflet; Thomas van Sloten; Blandine de Lauzon-Guillain; Jonathan Y Bernard; Patricia Dargent-Molina; Sabine Plancoulaine; Sandrine Lioret; Xavier Jouven; Marie-Alines Charles; Barbara Heude; Jean-Philippe Empana

doi:10.3389/fped.2022.827525

Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

Rachel E Climie^*, Muriel Tafflet, Thomas van Sloten, Blandine de Lauzon-Guillain, Jonathan Y Bernard, Patricia Dargent-Molina, Sabine Plancoulaine, Sandrine Lioret, Xavier Jouven, Marie-Alines Charles, Barbara Heude, Jean-Philippe Empana

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years.

Methods: Using data from the Etude sur les déterminants pré et post natals précoces du Développement psychomoteur et de la santé de l'Enfant (EDEN) study, a French population-based mother-child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence.

Results: Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13-2.78), children with intermediate (1.77, 1.05-2.98) or ideal (2.58, 1.38-4.82) behavioral CVH at age 3 years and children who spent < 30 min/day watching television (1.91, 1.09-3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64-5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders.

Conclusion: This study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.

Original language	English
Article number	827525
Number of pages	10
Journal	Frontiers in pediatrics
Volume	10
DOIs	https://doi.org/10.3389/fped.2022.827525
Publication status	Published - 11 Apr 2022

Keywords

ADULTHOOD
CHILDREN
DISEASE
EARLY-CHILDHOOD
IMPACT
METAANALYSIS
MORTALITY
PHYSICAL-ACTIVITY
PROMOTION
RISK-FACTORS
cardiovascular disease
childhood
determinants
neurodevelopment
primordial prevention

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10.3389/fped.2022.827525Licence: CC BY

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Climie, R. E., Tafflet, M., van Sloten, T., de Lauzon-Guillain, B., Bernard, J. Y., Dargent-Molina, P., Plancoulaine, S., Lioret, S., Jouven, X., Charles, M.-A., Heude, B., & Empana, J.-P. (2022). Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment. Frontiers in pediatrics, 10, Article 827525. https://doi.org/10.3389/fped.2022.827525

@article{a1659fb7cc2d449889ecb5708d1afd0f,

title = "Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment",

abstract = "Background: Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years.Methods: Using data from the Etude sur les d{\'e}terminants pr{\'e} et post natals pr{\'e}coces du D{\'e}veloppement psychomoteur et de la sant{\'e} de l'Enfant (EDEN) study, a French population-based mother-child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence.Results: Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13-2.78), children with intermediate (1.77, 1.05-2.98) or ideal (2.58, 1.38-4.82) behavioral CVH at age 3 years and children who spent < 30 min/day watching television (1.91, 1.09-3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64-5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders.Conclusion: This study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.",

keywords = "ADULTHOOD, CHILDREN, DISEASE, EARLY-CHILDHOOD, IMPACT, METAANALYSIS, MORTALITY, PHYSICAL-ACTIVITY, PROMOTION, RISK-FACTORS, cardiovascular disease, childhood, determinants, neurodevelopment, primordial prevention",

author = "Climie, {Rachel E} and Muriel Tafflet and {van Sloten}, Thomas and {de Lauzon-Guillain}, Blandine and Bernard, {Jonathan Y} and Patricia Dargent-Molina and Sabine Plancoulaine and Sandrine Lioret and Xavier Jouven and Marie-Alines Charles and Barbara Heude and Jean-Philippe Empana",

note = "Copyright {\textcopyright} 2022 Climie, Tafflet, Sloten, Lauzon-Guillain, Bernard, Dargent-Molina, Plancoulaine, Lioret, Jouven, Charles, Heude and Empana.",

year = "2022",

month = apr,

day = "11",

doi = "10.3389/fped.2022.827525",

language = "English",

volume = "10",

journal = "Frontiers in pediatrics",

issn = "2296-2360",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Cardiovascular Health at Age 5 Years

T2 - Distribution, Determinants, and Association With Neurodevelopment

AU - Climie, Rachel E

AU - Tafflet, Muriel

AU - van Sloten, Thomas

AU - de Lauzon-Guillain, Blandine

AU - Bernard, Jonathan Y

AU - Dargent-Molina, Patricia

AU - Plancoulaine, Sabine

AU - Lioret, Sandrine

AU - Jouven, Xavier

AU - Charles, Marie-Alines

AU - Heude, Barbara

AU - Empana, Jean-Philippe

PY - 2022/4/11

Y1 - 2022/4/11

N2 - Background: Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years.Methods: Using data from the Etude sur les déterminants pré et post natals précoces du Développement psychomoteur et de la santé de l'Enfant (EDEN) study, a French population-based mother-child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence.Results: Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13-2.78), children with intermediate (1.77, 1.05-2.98) or ideal (2.58, 1.38-4.82) behavioral CVH at age 3 years and children who spent < 30 min/day watching television (1.91, 1.09-3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64-5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders.Conclusion: This study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.

AB - Background: Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years.Methods: Using data from the Etude sur les déterminants pré et post natals précoces du Développement psychomoteur et de la santé de l'Enfant (EDEN) study, a French population-based mother-child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence.Results: Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13-2.78), children with intermediate (1.77, 1.05-2.98) or ideal (2.58, 1.38-4.82) behavioral CVH at age 3 years and children who spent < 30 min/day watching television (1.91, 1.09-3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64-5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders.Conclusion: This study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.

KW - ADULTHOOD

KW - CHILDREN

KW - DISEASE

KW - EARLY-CHILDHOOD

KW - IMPACT

KW - METAANALYSIS

KW - MORTALITY

KW - PHYSICAL-ACTIVITY

KW - PROMOTION

KW - RISK-FACTORS

KW - cardiovascular disease

KW - childhood

KW - determinants

KW - neurodevelopment

KW - primordial prevention

U2 - 10.3389/fped.2022.827525

DO - 10.3389/fped.2022.827525

M3 - Article

C2 - 35479759

SN - 2296-2360

VL - 10

JO - Frontiers in pediatrics

JF - Frontiers in pediatrics

M1 - 827525

ER -

Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

Abstract

Keywords

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