Cardiovascular health and sleep disturbances in two population-based cohort studies

Nadine Hausler, Quentin Lisan*, Thomas Van Sloten, Jose Haba-Rubio, Marie-Cecile Perier, Frederique Thomas, Nicolas Danchin, Catherine Guibout, Pierre Boutouyrie, Raphael Heinzer, Xavier Jouven, Pedro Marques-Vidal, Jean-Philippe Empana

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objective We aimed to investigate the association between cardiovascular health (CVH), as defined by the American Heart Association, and several sleep disturbances. Methods Two community-based cohorts, the Paris Prospective Study 3 (PPS3, France, n=6441) and the CoLaus study (Switzerland, n=2989) were analysed. CVH includes 7 metrics which all can be classified as poor, intermediate and ideal. Global CVH score was categorised into poor (0-2 ideal metrics), intermediate (3-4 ideal metrics) and ideal (>= 5 ideal metrics). Associations between global CVH and self-reported sleep disturbances (proxy of sleep-disordered breathing [SDB], excessive daytime sleepiness, insomnia symptoms and short/long sleep duration) and SDB severity measured by polysomnography (PSG) were investigated. Adjusted OR/relative risk ratio (RRR) and 95% CIs were estimated. Subjects with previous cardiovascular disease were excluded. Results Compared with poor CVH, subjects with intermediate and ideal global CVH had lower odds of self-reported SDB in both cohorts (ORs 0.55; 95% CI 0.44 to 0.68 and 0.35; 95% CI 0.22 to 0.53, respectively) and had lower SDB severity measured by PSG (RRR 0.07; 95% CI 0.02 to 0.20) in CoLaus. Subjects with intermediate and ideal global CVH had lower odds of excessive daytime sleepiness in PPS3 (ORs 0.82; 0.72 to 0.95 and 0.80; 0.82 to 1.02, respectively). No consistent associations were found between CVH and sleep duration or insomnia symptoms. Conclusions Higher levels of CVH are associated with lower odds of SDB and excessive daytime sleepiness. However, causal interpretation cannot be made and associations might be bidirectional.

Original languageEnglish
Pages (from-to)1500-1506
Number of pages7
Issue number19
Publication statusPublished - Oct 2019


  • AGE
  • cardiac risk factors and prevention
  • epidemiology

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