TY - JOUR
T1 - Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components
AU - Huang, Qi-Fang
AU - Aparicio, Lucas S.
AU - Thijs, Lutgarde
AU - Wei, Fang-Fei
AU - Melgarejo, Jesus D.
AU - Cheng, Yi-Bang
AU - Sheng, Chang-Sheng
AU - Yang, Wen-Yi
AU - Gilis-Malinowska, Natasza
AU - Boggia, Jose
AU - Niiranen, Teemu J.
AU - Wojciechowska, Wiktoria
AU - Stolarz-Skrzypek, Katarzyna
AU - Barochiner, Jessica
AU - Ackermann, Daniel
AU - Tikhonoff, Valerie
AU - Ponte, Belen
AU - Pruijm, Menno
AU - Casiglia, Edoardo
AU - Narkiewicz, Krzysztof
AU - Filipovsky, Jan
AU - Czarnecka, Danuta
AU - Kawecka-Jaszcz, Kalina
AU - Jula, Antti M.
AU - Bochud, Murielle
AU - Vanassche, Thomas
AU - Verhamme, Peter
AU - Struijker-Boudier, Harry A. J.
AU - Wang, Ji-Guang
AU - Zhang, Zhen-Yu
AU - Li, Yan
AU - Staessen, Jan A.
AU - IDCARS Investigators
PY - 2020/8
Y1 - 2020/8
N2 - Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, 5.0, 7.3, and 22.0 per 1000 person-years) with comparable estimates for cSBP, pSBP, and pPP. The multivariable-adjusted hazard ratios, expressing the risk per 1-SD increment in BP, were 1.50 (95% CI, 1.33-1.70) for cSBP, 1.36 (95% CI, 1.19-1.54) for cPP, 1.49 (95% CI, 1.33-1.67) for pSBP, and 1.34 (95% CI, 1.19-1.51) for pPP (P
AB - Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, 5.0, 7.3, and 22.0 per 1000 person-years) with comparable estimates for cSBP, pSBP, and pPP. The multivariable-adjusted hazard ratios, expressing the risk per 1-SD increment in BP, were 1.50 (95% CI, 1.33-1.70) for cSBP, 1.36 (95% CI, 1.19-1.54) for cPP, 1.49 (95% CI, 1.33-1.67) for pSBP, and 1.34 (95% CI, 1.19-1.51) for pPP (P
KW - blood pressure
KW - morbidity
KW - mortality
KW - population
KW - risk
KW - ASCENDING AORTIC PRESSURE
KW - LOCAL PULSE PRESSURE
KW - ARTERIAL STIFFNESS
KW - EVENTS
KW - DISEASE
KW - KIDNEY
U2 - 10.1161/HYPERTENSIONAHA.120.14787
DO - 10.1161/HYPERTENSIONAHA.120.14787
M3 - Article
C2 - 32639894
VL - 76
SP - 350
EP - 358
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -