Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population

Nicos Mitsides*, Tom Cornelis, Natascha J. H. Broers, Nanda M. P. Diederen, Paul Brenchley, Frank M. van der Sande, Casper Schalkwijk, Jeroen P. Kooman, Sandip Mitra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Background: Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. Methods: We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark- field capillaroscopy and vascular biomarkers. Results: EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Bio-marker profiles were similar in EHD and CHD but abnormal compared to healthy controls. Conclusion: Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias. (C) 2018 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalBlood Purification
Volume45
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Cardiovascular physiology
  • Extended dialysis
  • Inflammation
  • NOCTURNAL HOME HEMODIALYSIS
  • RANDOMIZED-CONTROLLED-TRIAL
  • ENDOTHELIAL SURFACE-LAYER
  • CONVENTIONAL HEMODIALYSIS
  • DIALYSIS PATIENTS
  • SURVIVAL
  • GLYCOCALYX
  • DISEASE

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