Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population

Nicos Mitsides; Tom Cornelis; Natascha J. H. Broers; Nanda M. P. Diederen; Paul Brenchley; Frank M. van der Sande; Casper Schalkwijk; Jeroen P. Kooman; Sandip Mitra

doi:10.1159/000485231

Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population

Nicos Mitsides^*, Tom Cornelis, Natascha J. H. Broers, Nanda M. P. Diederen, Paul Brenchley, Frank M. van der Sande, Casper Schalkwijk, Jeroen P. Kooman, Sandip Mitra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. Methods: We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark- field capillaroscopy and vascular biomarkers. Results: EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Bio-marker profiles were similar in EHD and CHD but abnormal compared to healthy controls. Conclusion: Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias. (C) 2018 S. Karger AG, Basel.

Original language	English
Pages (from-to)	356-363
Number of pages	8
Journal	Blood Purification
Volume	45
Issue number	4
DOIs	https://doi.org/10.1159/000485231
Publication status	Published - 1 Jan 2018

Keywords

Cardiovascular physiology
Extended dialysis
Inflammation
NOCTURNAL HOME HEMODIALYSIS
RANDOMIZED-CONTROLLED-TRIAL
ENDOTHELIAL SURFACE-LAYER
CONVENTIONAL HEMODIALYSIS
DIALYSIS PATIENTS
SURVIVAL
GLYCOCALYX
DISEASE

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10.1159/000485231

Cite this

@article{40a8aadbd55c4eb9bd829740fb04ed2c,

title = "Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population",

abstract = "Background: Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. Methods: We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark- field capillaroscopy and vascular biomarkers. Results: EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Bio-marker profiles were similar in EHD and CHD but abnormal compared to healthy controls. Conclusion: Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias. (C) 2018 S. Karger AG, Basel.",

keywords = "Cardiovascular physiology, Extended dialysis, Inflammation, NOCTURNAL HOME HEMODIALYSIS, RANDOMIZED-CONTROLLED-TRIAL, ENDOTHELIAL SURFACE-LAYER, CONVENTIONAL HEMODIALYSIS, DIALYSIS PATIENTS, SURVIVAL, GLYCOCALYX, DISEASE",

author = "Nicos Mitsides and Tom Cornelis and Broers, {Natascha J. H.} and Diederen, {Nanda M. P.} and Paul Brenchley and {van der Sande}, {Frank M.} and Casper Schalkwijk and Kooman, {Jeroen P.} and Sandip Mitra",

year = "2018",

month = jan,

day = "1",

doi = "10.1159/000485231",

language = "English",

volume = "45",

pages = "356--363",

journal = "Blood Purification",

issn = "0253-5068",

publisher = "Karger",

number = "4",

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TY - JOUR

T1 - Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population

AU - Mitsides, Nicos

AU - Cornelis, Tom

AU - Broers, Natascha J. H.

AU - Diederen, Nanda M. P.

AU - Brenchley, Paul

AU - van der Sande, Frank M.

AU - Schalkwijk, Casper

AU - Kooman, Jeroen P.

AU - Mitra, Sandip

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. Methods: We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark- field capillaroscopy and vascular biomarkers. Results: EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Bio-marker profiles were similar in EHD and CHD but abnormal compared to healthy controls. Conclusion: Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias. (C) 2018 S. Karger AG, Basel.

AB - Background: Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. Methods: We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark- field capillaroscopy and vascular biomarkers. Results: EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Bio-marker profiles were similar in EHD and CHD but abnormal compared to healthy controls. Conclusion: Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias. (C) 2018 S. Karger AG, Basel.

KW - Cardiovascular physiology

KW - Extended dialysis

KW - Inflammation

KW - NOCTURNAL HOME HEMODIALYSIS

KW - RANDOMIZED-CONTROLLED-TRIAL

KW - ENDOTHELIAL SURFACE-LAYER

KW - CONVENTIONAL HEMODIALYSIS

KW - DIALYSIS PATIENTS

KW - SURVIVAL

KW - GLYCOCALYX

KW - DISEASE

U2 - 10.1159/000485231

DO - 10.1159/000485231

M3 - Article

SN - 0253-5068

VL - 45

SP - 356

EP - 363

JO - Blood Purification

JF - Blood Purification

IS - 4

ER -