TY - JOUR
T1 - Cardiovascular 3D bioprinting
T2 - A review on cardiac tissue development
AU - Kalhori, Dianoosh
AU - Zakeri, Nima
AU - Zafar-Jafarzadeh, Mahshid
AU - Moroni, Lorenzo
AU - Solati-Hashjin, Mehran
N1 - Funding Information:
The authors would also like to thank Dr. Mitra Asadi-Eydivand, Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Iran and Dr. Sasan Jalili, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA for assisting in designing and preparation of the graphical abstract. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Cardiovascular diseases such as myocardial infarction account for millions of worldwide deaths annually. Cardiovascular tissues constitute a highly organized and complex three-dimensional (3D) structure that makes them hard to fabricate in a biomimetic manner by conventional scaffold fabrication methods. 3D bioprinting has been introduced as a novel cell-based method in the last two decades due to its ability to recapitulate cell density, multicellular architecture, physiochemical environment, and vascularization of biological constructs with accurate designs. This review article aims to provide a comprehensive outlook to obtain cardiovascular functional tissues from the engineering of bioinks comprising cells, hydrogels, and biofactors to bioprinting techniques and relevant biophysical stimulations responsible for maturation and tissue-level functions. Also, cardiac tissue 3D bioprinting investigations and further discussion over its challenges and perspectives are highlighted in this review article.
AB - Cardiovascular diseases such as myocardial infarction account for millions of worldwide deaths annually. Cardiovascular tissues constitute a highly organized and complex three-dimensional (3D) structure that makes them hard to fabricate in a biomimetic manner by conventional scaffold fabrication methods. 3D bioprinting has been introduced as a novel cell-based method in the last two decades due to its ability to recapitulate cell density, multicellular architecture, physiochemical environment, and vascularization of biological constructs with accurate designs. This review article aims to provide a comprehensive outlook to obtain cardiovascular functional tissues from the engineering of bioinks comprising cells, hydrogels, and biofactors to bioprinting techniques and relevant biophysical stimulations responsible for maturation and tissue-level functions. Also, cardiac tissue 3D bioprinting investigations and further discussion over its challenges and perspectives are highlighted in this review article.
KW - 3D bioprinting
KW - Bioink
KW - Cardiac tissue engineering
KW - Cardiomyocytes
KW - Cardiovascular tissue engineering
KW - Hydrogels
U2 - 10.1016/j.bprint.2022.e00221
DO - 10.1016/j.bprint.2022.e00221
M3 - (Systematic) Review article
SN - 2405-8866
VL - 28
JO - Bioprinting
JF - Bioprinting
M1 - e00221
ER -