Cardiometabolic risk modulation in normal-weight COPD

Research output: ThesisDoctoral ThesisInternal


Patients with COPD have an increased risk of developing cardiometabolic diseases such as type 2 diabetes and cardiovascular disease. This dissertation found that the risk not only increases in overweight patients, but also in normal-weight patients with abdominal obesity and low muscle mass. Standard nutrition and exercise interventions in this group of patients focus on improving muscle function and endurance; however, this dissertation found that these interventions did not affect cardiometabolic risk. Instead, lifestyle changes are recommended for this group of patients. We also conducted a controlled experiment to determine whether nitrate has a beneficial effect on cardiometabolic risk, but this was not the case.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Schols, Annemie, Supervisor
  • Gosker, Harry, Advisor
  • van den Borst, B., Advisor, External person
Award date29 Jun 2018
Publication statusPublished - 2018


  • COPD
  • cardiometabolic risk
  • normal body weight
  • low muscle mass
  • abdominal obesity
  • nitrate
  • resveratrol
  • exercise

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