CARDIODETECT RAPID TEST FOR THE DIAGNOSIS OF EARLY ACUTE MYOCARDIAL INFARCTION

Yan Liang, Cangel P. Y. Chan, Kwan-yee Cheung, George W. H. Cautherley, Jan F. C. Glatz, Reinhard Renneberg, Jun Zhu*

*Corresponding author for this work

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Abstract

Two hundreds patients suspected of acute myocardial infarction presenting to the hospital with a median symptom onset of 2.3 h (IQR 1.7-4.0 h) were enrolled in this study. The diagnostic performances of CardioDetect (R), a one-step immunotest for heart-type fatty acid-binding protein (H-FABP), and its combination with cardiac troponin I (cTnI) at admission and 2 h after admission, were compared with different cardiac markers. The H-FABP immunotest had better sensitivities (76.6% and 94.4%) than the other cardiac markers and better specificities (88.2% and 81.7%) than myoglobin at admission and 2 h after admission. Both sensitivity and negative predictive value increased to over 90.0% at 2 h after admission. The areas under the receiver operator characteristic curve for the combination of H-FABP with cTnI were the greatest at admission [0.834 (95% CI: 0.774-0.894)].
Original languageEnglish
Pages (from-to)342-352
JournalJournal of Immunoassay & Immunochemistry
Volume32
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • acute myocardial infarction
  • cardiac marker
  • cardiac troponin I
  • diagnosis
  • heart-type fatty acid-binding protein
  • myoglobin

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