Cardiac shockwave therapy in patients with chronic refractory angina pectoris

J. Vainer*, J. H. M. Habets, S. Schalla, A. H. P. Lousberg, C. D. J. M. de Pont, Stefan Vöö, B.T. Brans, J. C. A. Hoorntje, J. Waltenberger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)


Background Cardiac shockwave therapy (CSWT) might improve symptoms and decrease ischaemia burden by stimulating collateral growth in chronic ischaemic myocardium. This prospective study was performed to evaluate the feasibility and safety of CSWT. Methods We included 33 patients (mean age 70 7 years, mean left ventricular ejection fraction 55 +/- 12 %) with end stage coronary artery disease, chronic angina pectoris and reversible ischaemia on myocardial scintigraphy. CSWT was applied to the ischaemic zones (3-7 spots/session, 100 impulses/spot, 0.09 mJ/mm(2)) in an echocardiography-guided and ECG-triggered fashion. The protocol included a total of 9 treatment sessions (3 treatment sessions within 1 week at baseline, and after 1 and 2 months). Clinical assessment was performed using exercise testing, angina score (CCS class), nitrate use, myocardial scintigraphy, and cardiac magnetic resonance (CMR) 1 and 4 months after the last treatment session. Results One and 4 months after CSWT, sublingual nitrate use decreased from 10/week to 2/week (p <0.01) and the angina symptoms diminished from CCS class III to CCS class II (p
Original languageEnglish
Pages (from-to)343-349
JournalNetherlands Heart Journal
Issue number5
Publication statusPublished - May 2016


  • Angina, stable
  • Myocardial ischaemia
  • Radionuclide imaging
  • Echocardiography
  • Shock Waves
  • Ultrasonic

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