Cardiac remodeling in normotensive pregnancy and in pregnancy complicated by hypertension: systematic review and meta-analysis

S. de Haas*, C. Ghossein-Doha, L. Geerts, S. M. J. van Kuijk, J. van Drongelen, M. E. A. Spaanderman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Web of Science)

Abstract

Objective The aim of this systematic review and meta-analysis was to describe comprehensively the pattern of cardiac remodeling during normotensive human singleton pregnancy and to compare it with that of pregnancy complicated by hypertension.

Methods We performed a meta-analysis of the current literature on cardiac remodeling during normotensive and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and EMBASE (Ovid) databases. Included studies needed to report a reference measurement (matched non-pregnant control group, prepregnancy or postpartum) and measurements made during predetermined gestational-age intervals. Mean differences between reference and pregnancy data were calculated using the random-effects model described by DerSimonian and Laird.

Results Forty-eight studies were included in the meta-analysis, with publication dates ranging from 1977 to 2016. During normotensive pregnancy, most geometric indices started to increase in the second trimester. Left ventricular mass (LVM) increased by 28.36 (95% CI, 19.73-37.00) g (24%), and relative wall thickness (RWT) increased by 0.03 (95% CI, 0.02-0.05) (10%) compared with those in the reference group. During hypertensive pregnancy, LVM and RWT increased more than during normotensive pregnancy (92 (95% CI, 75.46-108.54) g (95%) and 0.14 (95% CI, 0.09-0.19) (56%), respectively).

Conclusions During normotensive pregnancy, most cardiac geometric indices change from the second trimester onwards. Both LVM and RWT increase, by 20% and 10%, respectively, consistent with concentric rather than eccentric remodeling. Cardiac adaptation in hypertensive pregnancy deviates from that in healthy pregnancy by a greater change in LVM (95% increase from reference) and RWT (56% increase from reference). Copyright (C) 2017 ISUOG. Published by John Wiley & Sons Ltd.

Original languageEnglish
Pages (from-to)683-696
Number of pages14
JournalUltrasound in Obstetrics & Gynecology
Volume50
Issue number6
DOIs
Publication statusPublished - Dec 2017

Keywords

  • cardiac geometry
  • cardiac remodeling
  • complicated pregnancy
  • physiology
  • pre-eclampsia
  • pregnancy
  • LEFT-VENTRICULAR FUNCTION
  • NATRIURETIC-PEPTIDE CONCENTRATIONS
  • SPECKLE-TRACKING ECHOCARDIOGRAPHY
  • TOTAL VASCULAR-RESISTANCE
  • PLASMA-VOLUME
  • DIASTOLIC FUNCTION
  • PHYSIOLOGICAL ADAPTATION
  • PREECLAMPTIC PREGNANCY
  • FUNCTIONAL-CHANGES
  • WOMEN

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