Cardiac multi-marker strategy for effective diagnosis of acute myocardial infarction

Qin Xu; Cangel P. Y. Chan; Xiao-yao Cao; Peng Peng; Maisumu Mahemuti; Qi Sun; Kwan-yee Cheung; Wai-sze Ip; Xin-rong Zhou; Ge-yang Hu; Xiao-feng Zhang; Jiasharete Jielile; Yao-dong Li; Rong Ren; Jan F. C. Glatz; Reinhard Renneberg

doi:10.1016/j.cca.2010.07.033

Cardiac multi-marker strategy for effective diagnosis of acute myocardial infarction

Qin Xu, Cangel P. Y. Chan^*, Xiao-yao Cao, Peng Peng, Maisumu Mahemuti, Qi Sun, Kwan-yee Cheung, Wai-sze Ip, Xin-rong Zhou, Ge-yang Hu, Xiao-feng Zhang, Jiasharete Jielile, Yao-dong Li, Rong Ren, Jan F. C. Glatz, Reinhard Renneberg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background Heart-type fatty acid-binding protein (H-FABP) is a heart-specific and highly sensitive biomarker for early diagnosis of acute myocardial infarction (AMI) We investigated the effectiveness of H-FABP for diagnosis of AMI in patients with different ethnic background and different time from symptom onset. Methods Venous blood was withdrawn from consecutive patients with acute chest pain admitted to the First Affiliated Hospital of Xinjiang Medical University. The blood samples were used for measurement of creatine kinase MB (CK-MB) and cardiac troponin 1 (cTnl) using Beckman Coulter DC-800 analyzer, and detection of H-FABP using a one-step bedside immunotest Results Two hundred and eighty-nine patients admitted within 1211 after the onset of symptoms were recruited in the study The H-FABP immunotest was found to have higher diagnostic accuracy than cTnl and CK-MB in patients admitted within 3 h The combination of H-FABP and cTnl was found to have the highest diagnostic accuracy (91%) among different cardiac markers and the other combinations It gave the highest sensitivity [96% (95% Cl. 91-98%)] and a comparable specificity [84% (95% Cl: 76-89%)] to cTnl alone. Conclusion: A cardiac panel consisting of H-FABP and troponin is recommended

Original language	English
Pages (from-to)	1781-1787
Journal	Clinica Chimica Acta
Volume	411
Issue number	21-22
DOIs	https://doi.org/10.1016/j.cca.2010.07.033
Publication status	Published - 11 Nov 2010

Keywords

Acute myocardial infarction (AMI)
Cardiac troponin l (cTnl)
Creatine kinase MB (CK-MB)
Heart-type fatty acid-binding protein (H-FABP)
Multi-marker

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10.1016/j.cca.2010.07.033

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Cite this

@article{ed0dfa0237b04ffea34929678834791c,

title = "Cardiac multi-marker strategy for effective diagnosis of acute myocardial infarction",

abstract = "Background Heart-type fatty acid-binding protein (H-FABP) is a heart-specific and highly sensitive biomarker for early diagnosis of acute myocardial infarction (AMI) We investigated the effectiveness of H-FABP for diagnosis of AMI in patients with different ethnic background and different time from symptom onset. Methods Venous blood was withdrawn from consecutive patients with acute chest pain admitted to the First Affiliated Hospital of Xinjiang Medical University. The blood samples were used for measurement of creatine kinase MB (CK-MB) and cardiac troponin 1 (cTnl) using Beckman Coulter DC-800 analyzer, and detection of H-FABP using a one-step bedside immunotest Results Two hundred and eighty-nine patients admitted within 1211 after the onset of symptoms were recruited in the study The H-FABP immunotest was found to have higher diagnostic accuracy than cTnl and CK-MB in patients admitted within 3 h The combination of H-FABP and cTnl was found to have the highest diagnostic accuracy (91%) among different cardiac markers and the other combinations It gave the highest sensitivity [96% (95% Cl. 91-98%)] and a comparable specificity [84% (95% Cl: 76-89%)] to cTnl alone. Conclusion: A cardiac panel consisting of H-FABP and troponin is recommended ",

keywords = "Acute myocardial infarction (AMI), Cardiac troponin l (cTnl), Creatine kinase MB (CK-MB), Heart-type fatty acid-binding protein (H-FABP), Multi-marker",

author = "Qin Xu and Chan, {Cangel P. Y.} and Xiao-yao Cao and Peng Peng and Maisumu Mahemuti and Qi Sun and Kwan-yee Cheung and Wai-sze Ip and Xin-rong Zhou and Ge-yang Hu and Xiao-feng Zhang and Jiasharete Jielile and Yao-dong Li and Rong Ren and Glatz, {Jan F. C.} and Reinhard Renneberg",

year = "2010",

month = nov,

day = "11",

doi = "10.1016/j.cca.2010.07.033",

language = "English",

volume = "411",

pages = "1781--1787",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier",

number = "21-22",

}

TY - JOUR

T1 - Cardiac multi-marker strategy for effective diagnosis of acute myocardial infarction

AU - Xu, Qin

AU - Chan, Cangel P. Y.

AU - Cao, Xiao-yao

AU - Peng, Peng

AU - Mahemuti, Maisumu

AU - Sun, Qi

AU - Cheung, Kwan-yee

AU - Ip, Wai-sze

AU - Zhou, Xin-rong

AU - Hu, Ge-yang

AU - Zhang, Xiao-feng

AU - Jielile, Jiasharete

AU - Li, Yao-dong

AU - Ren, Rong

AU - Glatz, Jan F. C.

AU - Renneberg, Reinhard

PY - 2010/11/11

Y1 - 2010/11/11

N2 - Background Heart-type fatty acid-binding protein (H-FABP) is a heart-specific and highly sensitive biomarker for early diagnosis of acute myocardial infarction (AMI) We investigated the effectiveness of H-FABP for diagnosis of AMI in patients with different ethnic background and different time from symptom onset. Methods Venous blood was withdrawn from consecutive patients with acute chest pain admitted to the First Affiliated Hospital of Xinjiang Medical University. The blood samples were used for measurement of creatine kinase MB (CK-MB) and cardiac troponin 1 (cTnl) using Beckman Coulter DC-800 analyzer, and detection of H-FABP using a one-step bedside immunotest Results Two hundred and eighty-nine patients admitted within 1211 after the onset of symptoms were recruited in the study The H-FABP immunotest was found to have higher diagnostic accuracy than cTnl and CK-MB in patients admitted within 3 h The combination of H-FABP and cTnl was found to have the highest diagnostic accuracy (91%) among different cardiac markers and the other combinations It gave the highest sensitivity [96% (95% Cl. 91-98%)] and a comparable specificity [84% (95% Cl: 76-89%)] to cTnl alone. Conclusion: A cardiac panel consisting of H-FABP and troponin is recommended

AB - Background Heart-type fatty acid-binding protein (H-FABP) is a heart-specific and highly sensitive biomarker for early diagnosis of acute myocardial infarction (AMI) We investigated the effectiveness of H-FABP for diagnosis of AMI in patients with different ethnic background and different time from symptom onset. Methods Venous blood was withdrawn from consecutive patients with acute chest pain admitted to the First Affiliated Hospital of Xinjiang Medical University. The blood samples were used for measurement of creatine kinase MB (CK-MB) and cardiac troponin 1 (cTnl) using Beckman Coulter DC-800 analyzer, and detection of H-FABP using a one-step bedside immunotest Results Two hundred and eighty-nine patients admitted within 1211 after the onset of symptoms were recruited in the study The H-FABP immunotest was found to have higher diagnostic accuracy than cTnl and CK-MB in patients admitted within 3 h The combination of H-FABP and cTnl was found to have the highest diagnostic accuracy (91%) among different cardiac markers and the other combinations It gave the highest sensitivity [96% (95% Cl. 91-98%)] and a comparable specificity [84% (95% Cl: 76-89%)] to cTnl alone. Conclusion: A cardiac panel consisting of H-FABP and troponin is recommended

KW - Acute myocardial infarction (AMI)

KW - Cardiac troponin l (cTnl)

KW - Creatine kinase MB (CK-MB)

KW - Heart-type fatty acid-binding protein (H-FABP)

KW - Multi-marker

U2 - 10.1016/j.cca.2010.07.033

DO - 10.1016/j.cca.2010.07.033

M3 - Article

C2 - 20691169

SN - 0009-8981

VL - 411

SP - 1781

EP - 1787

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 21-22

ER -