Cardiac multi-marker strategy for effective diagnosis of acute myocardial infarction

Qin Xu, Cangel P. Y. Chan*, Xiao-yao Cao, Peng Peng, Maisumu Mahemuti, Qi Sun, Kwan-yee Cheung, Wai-sze Ip, Xin-rong Zhou, Ge-yang Hu, Xiao-feng Zhang, Jiasharete Jielile, Yao-dong Li, Rong Ren, Jan F. C. Glatz, Reinhard Renneberg

*Corresponding author for this work

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Abstract

Background Heart-type fatty acid-binding protein (H-FABP) is a heart-specific and highly sensitive biomarker for early diagnosis of acute myocardial infarction (AMI) We investigated the effectiveness of H-FABP for diagnosis of AMI in patients with different ethnic background and different time from symptom onset. Methods Venous blood was withdrawn from consecutive patients with acute chest pain admitted to the First Affiliated Hospital of Xinjiang Medical University. The blood samples were used for measurement of creatine kinase MB (CK-MB) and cardiac troponin 1 (cTnl) using Beckman Coulter DC-800 analyzer, and detection of H-FABP using a one-step bedside immunotest Results Two hundred and eighty-nine patients admitted within 1211 after the onset of symptoms were recruited in the study The H-FABP immunotest was found to have higher diagnostic accuracy than cTnl and CK-MB in patients admitted within 3 h The combination of H-FABP and cTnl was found to have the highest diagnostic accuracy (91%) among different cardiac markers and the other combinations It gave the highest sensitivity [96% (95% Cl. 91-98%)] and a comparable specificity [84% (95% Cl: 76-89%)] to cTnl alone. Conclusion: A cardiac panel consisting of H-FABP and troponin is recommended
Original languageEnglish
Pages (from-to)1781-1787
JournalClinica Chimica Acta
Volume411
Issue number21-22
DOIs
Publication statusPublished - 11 Nov 2010

Keywords

  • Acute myocardial infarction (AMI)
  • Cardiac troponin l (cTnl)
  • Creatine kinase MB (CK-MB)
  • Heart-type fatty acid-binding protein (H-FABP)
  • Multi-marker

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