Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease

Giuseppe Vergaro; Alberto Aimo; James L Januzzi; A Mark Richards; Carolyn S P Lam; Roberto Latini; Lidia Staszewsky; Inder S Anand; Thor Ueland; Hans-Peter Brunner-La Rocca; Antoni Bayes-Genis; Josep Lupón; Rudolf A de Boer; Akiomi Yoshihisa; Yasuchika Takeishi; Ida Gustafsson; Kai M Eggers; Kurt Huber; Greg D Gamble; Kui Toh Gerard Leong; Poh Shuan Daniel Yeo; Hean Yee Ong; Fazlur Jaufeerally; Tze P Ng; Richard Troughton; Robert N Doughty; Michele Emdin; Claudio Passino

doi:10.2459/JCM.0000000000001281

Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease

Giuseppe Vergaro, Alberto Aimo^*, James L Januzzi, A Mark Richards, Carolyn S P Lam, Roberto Latini, Lidia Staszewsky, Inder S Anand, Thor Ueland, Hans-Peter Brunner-La Rocca, Antoni Bayes-Genis, Josep Lupón, Rudolf A de Boer, Akiomi Yoshihisa, Yasuchika Takeishi, Ida Gustafsson, Kai M Eggers, Kurt Huber, Greg D Gamble, Kui Toh Gerard LeongPoh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P Ng, Richard Troughton, Robert N Doughty, Michele Emdin, Claudio Passino

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).

METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.

RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5-2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.

CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

Original language	English
Pages (from-to)	28-36
Number of pages	9
Journal	Journal of Cardiovascular Medicine
Volume	23
Issue number	1
DOIs	https://doi.org/10.2459/JCM.0000000000001281
Publication status	Published - 1 Jan 2022

Keywords

Aged
Biomarkers/blood
Female
Forced Expiratory Volume
Heart Failure/mortality
Hospitalization
Humans
Interleukin-1 Receptor-Like 1 Protein/blood
Male
Middle Aged
Natriuretic Peptide, Brain/blood
Peptide Fragments/blood
Prognosis
Pulmonary Disease, Chronic Obstructive/mortality
Severity of Illness Index
Troponin T/blood

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Vergaro, G., Aimo, A., Januzzi, J. L., Richards, A. M., Lam, C. S. P., Latini, R., Staszewsky, L., Anand, I. S., Ueland, T., Brunner-La Rocca, H.-P., Bayes-Genis, A., Lupón, J., de Boer, R. A., Yoshihisa, A., Takeishi, Y., Gustafsson, I., Eggers, K. M., Huber, K., Gamble, G. D., ... Passino, C. (2022). Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. Journal of Cardiovascular Medicine, 23(1), 28-36. https://doi.org/10.2459/JCM.0000000000001281

@article{d5f11314ce0c4b3c8709bb4da7383e6d,

title = "Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease",

abstract = "AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77\% were men and 82\% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15\%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5-2.5), 1717 patients (21\%) died, and 1298 (16\%) died from cardiovascular causes; 2255 patients (28\%) were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.",

keywords = "Aged, Biomarkers/blood, Female, Forced Expiratory Volume, Heart Failure/mortality, Hospitalization, Humans, Interleukin-1 Receptor-Like 1 Protein/blood, Male, Middle Aged, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Prognosis, Pulmonary Disease, Chronic Obstructive/mortality, Severity of Illness Index, Troponin T/blood",

author = "Giuseppe Vergaro and Alberto Aimo and Januzzi, \{James L\} and Richards, \{A Mark\} and Lam, \{Carolyn S P\} and Roberto Latini and Lidia Staszewsky and Anand, \{Inder S\} and Thor Ueland and \{Brunner-La Rocca\}, Hans-Peter and Antoni Bayes-Genis and Josep Lup{\'o}n and \{de Boer\}, \{Rudolf A\} and Akiomi Yoshihisa and Yasuchika Takeishi and Ida Gustafsson and Eggers, \{Kai M\} and Kurt Huber and Gamble, \{Greg D\} and Leong, \{Kui Toh Gerard\} and Yeo, \{Poh Shuan Daniel\} and Ong, \{Hean Yee\} and Fazlur Jaufeerally and Ng, \{Tze P\} and Richard Troughton and Doughty, \{Robert N\} and Michele Emdin and Claudio Passino",

year = "2022",

month = jan,

day = "1",

doi = "10.2459/JCM.0000000000001281",

language = "English",

volume = "23",

pages = "28--36",

journal = "Journal of Cardiovascular Medicine",

issn = "1558-2027",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "1",

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Vergaro, G, Aimo, A, Januzzi, JL, Richards, AM, Lam, CSP, Latini, R, Staszewsky, L, Anand, IS, Ueland, T, Brunner-La Rocca, H-P, Bayes-Genis, A, Lupón, J, de Boer, RA, Yoshihisa, A, Takeishi, Y, Gustafsson, I, Eggers, KM, Huber, K, Gamble, GD, Leong, KTG, Yeo, PSD, Ong, HY, Jaufeerally, F, Ng, TP, Troughton, R, Doughty, RN, Emdin, M & Passino, C 2022, 'Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease', Journal of Cardiovascular Medicine, vol. 23, no. 1, pp. 28-36. https://doi.org/10.2459/JCM.0000000000001281

TY - JOUR

T1 - Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease

AU - Vergaro, Giuseppe

AU - Aimo, Alberto

AU - Januzzi, James L

AU - Richards, A Mark

AU - Lam, Carolyn S P

AU - Latini, Roberto

AU - Staszewsky, Lidia

AU - Anand, Inder S

AU - Ueland, Thor

AU - Brunner-La Rocca, Hans-Peter

AU - Bayes-Genis, Antoni

AU - Lupón, Josep

AU - de Boer, Rudolf A

AU - Yoshihisa, Akiomi

AU - Takeishi, Yasuchika

AU - Gustafsson, Ida

AU - Eggers, Kai M

AU - Huber, Kurt

AU - Gamble, Greg D

AU - Leong, Kui Toh Gerard

AU - Yeo, Poh Shuan Daniel

AU - Ong, Hean Yee

AU - Jaufeerally, Fazlur

AU - Ng, Tze P

AU - Troughton, Richard

AU - Doughty, Robert N

AU - Emdin, Michele

AU - Passino, Claudio

PY - 2022/1/1

Y1 - 2022/1/1

N2 - AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5-2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

AB - AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5-2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

KW - Aged

KW - Biomarkers/blood

KW - Female

KW - Forced Expiratory Volume

KW - Heart Failure/mortality

KW - Hospitalization

KW - Humans

KW - Interleukin-1 Receptor-Like 1 Protein/blood

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Prognosis

KW - Pulmonary Disease, Chronic Obstructive/mortality

KW - Severity of Illness Index

KW - Troponin T/blood

U2 - 10.2459/JCM.0000000000001281

DO - 10.2459/JCM.0000000000001281

M3 - Article

C2 - 34839321

SN - 1558-2027

VL - 23

SP - 28

EP - 36

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

IS - 1

ER -

Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease

Abstract

Keywords

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