TY - JOUR
T1 - Candidate system analysis in ADHD: Evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1
AU - Ribases, Marta
AU - Antoni Ramos-Quiroga, Josep
AU - Hervas, Amaia
AU - Sanchez-Mora, Cristina
AU - Bosch, Rosa
AU - Bielsa, Anna
AU - Gastaminza, Xavier
AU - Lesch, Klaus-Peter
AU - Reif, Andreas
AU - Renner, Tobias J
AU - Romanos, Marcel
AU - Warnke, Andreas
AU - Walitza, Susanne
AU - Freitag, Christine M.
AU - Meyer, Jobst
AU - Palmason, Haukur
AU - Casas, Miquel
AU - Bayes, Monica
AU - Cormand, Bru
PY - 2012/4
Y1 - 2012/4
N2 - Several pharmacological and genetic studies support the involvement of the dopamine neurotransmitter system in the aetiology of attention-deficit hyperactivity disorder (ADHD). Based on this information we evaluated the contribution to ADHD of nine genes involved in dopaminergic neurotransmission (DRD1, DRD2, DRD3, DRD4, DRD5, DAT1, TH, DBH and COMT).We genotyped a total of 61 tagging single nucleotide polymorphisms (SNPs) in a sample of 533 ADHD patients (322 children and 211 adults), 533 sex-matched unrelated controls and additional 196 nuclear ADHD families from Spain.The single- and multiple-marker analysis in both population and family-based approaches provided preliminary evidence for the contribution of DRD1 to combined-type ADHD in children (P=8.8e-04; OR=1.50 (1.18-1.90) and P=0.0061; OR=1.73 (1.23-2.45)) but not in adults. Subsequently, we tested positive results for replication in an independent sample of 353 German families with combined-type ADHD children and replicated the initial association between DRD1 and childhood ADHD (P=8.4e-05; OR=3.67 (2.04-6.63)).The replication of the association between DRD1 and ADHD in two European cohorts highlights the validity of our finding and supports the involvement of DRD1 in childhood ADHD.
AB - Several pharmacological and genetic studies support the involvement of the dopamine neurotransmitter system in the aetiology of attention-deficit hyperactivity disorder (ADHD). Based on this information we evaluated the contribution to ADHD of nine genes involved in dopaminergic neurotransmission (DRD1, DRD2, DRD3, DRD4, DRD5, DAT1, TH, DBH and COMT).We genotyped a total of 61 tagging single nucleotide polymorphisms (SNPs) in a sample of 533 ADHD patients (322 children and 211 adults), 533 sex-matched unrelated controls and additional 196 nuclear ADHD families from Spain.The single- and multiple-marker analysis in both population and family-based approaches provided preliminary evidence for the contribution of DRD1 to combined-type ADHD in children (P=8.8e-04; OR=1.50 (1.18-1.90) and P=0.0061; OR=1.73 (1.23-2.45)) but not in adults. Subsequently, we tested positive results for replication in an independent sample of 353 German families with combined-type ADHD children and replicated the initial association between DRD1 and childhood ADHD (P=8.4e-05; OR=3.67 (2.04-6.63)).The replication of the association between DRD1 and ADHD in two European cohorts highlights the validity of our finding and supports the involvement of DRD1 in childhood ADHD.
KW - Genetics
KW - biological psychiatry
KW - childhood ADHD
KW - DRD1
KW - association study
U2 - 10.3109/15622975.2011.584905
DO - 10.3109/15622975.2011.584905
M3 - Article
C2 - 22404661
SN - 1562-2975
VL - 13
SP - 281
EP - 292
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
IS - 4
ER -