Can the preterm lung recover from perinatal stress?

Matthias Hütten, Tim Wolfs, Boris Kramer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfere with fetal and neonatal lung development. Prenatal insults like chorioamnionitis and prenatal interventions like maternal glucocorticosteroids interact but might also determine the preterm baby's lung response to postnatal interventions ("second hit") like supplementation of oxygen and drug therapy. We review current experimental and clinical findings on the influence of different perinatal factors on preterm lung development and discuss how well-established interventions in neonatal care might be adapted to attenuate postnatal lung injury.
Original languageEnglish
Article number15
JournalMolecular and Cellular Pediatrics
Issue number1
Publication statusPublished - 2016

Cite this