The number of people suffering from metabolic diseases is dramatically worldwide. This stresses the need for new therapeutic strategies to growing epidemic of metabolic diseases. A reduced mitochondrial function of the characteristics of metabolic diseases and therefore a target for intervention. Here we review the evidence that mitochondrial function a target to treat and prevent type 2 diabetes mellitus, and, if so, effects are due to reduction in skeletal muscle fat accumulation. We exercise may affect these parameters and can be beneficial for type 2 We next focus on alternative ways to improve mitochondrial function in a non-exercise manner. Thus, in 2003, resveratrol (3,5,4'- discovered to be a small molecule activator of sirtuin 1, an important target regulating cellular energy metabolism and mitochondrial Rodent studies have clearly demonstrated the potential of resveratrol to various metabolic health parameters. Here we review data in human is available on the effects of resveratrol on metabolism and function and discuss how resveratrol may serve as a new therapeutic preserve metabolic health. We also discuss whether the effects of similar to the effects of exercise training and therefore if resveratrol considered as an exercise mimetic.