Can IM-MS Collision Cross Sections of Biomolecules Be Rationalized Using Collision Cross-Section Trends of Polydisperse Synthetic Homopolymers?

Jean R. N. Haler*, Philippe Massonnet, Johann Far, Gregory Upert, Nicolas Gilles, Gilles Mourier, Loic Quinton, Edwin De Pauw

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In the past, we developed a method inferring physicochemical properties from ion mobility mass spectrometry (IM-MS) data from polydisperse synthetic homopolymers. We extend here the method to biomolecules that are generally monodisperse. Similarities in the IM-MS behavior were illustrated on proteins and peptides. This allows one to identify ionic species for which intramolecular interactions lead to specific structures.

Original languageEnglish
Pages (from-to)990-995
Number of pages6
JournalJournal of the American Society for Mass Spectrometry
Volume31
Issue number4
DOIs
Publication statusPublished - 1 Apr 2020

Keywords

  • MOBILITY-MASS-SPECTROMETRY
  • DRIFT-TUBE
  • GAS
  • PEPTIDES
  • POLYMERS
  • ISOMERS
  • IONS

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