Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial

Carlos Celis-Morales, Cyril F. M. Marsaux, Katherine M. Livingstone, Santiago Navas-Carretero, Rodrigo San-Cristobal, Rosalind Fallaize, Anna L. Macready, Clare O'Donovan, Clara Woolhead, Hannah Forster, Silvia Kolossa, Hannelore Daniel, George Moschonis, Christina Mavrogianni, Yannis Manios, Agnieszka Surwillo, Iwona Traczyk, Christian A. Drevon, Keith Grimaldi, Jildau BouwmanMike J. Gibney, Marianne C. Walsh, Eileen R. Gibney, Lorraine Brennan, Julie A. Lovegrove, J. Alfredo Martinez, Wim H. M. Saris, John C. Mathers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Web of Science)

Abstract

Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fitsall advice.

Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.

Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6.

Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)].

Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene.

Original languageEnglish
Pages (from-to)1204-1213
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume105
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • FTO
  • genotype
  • personalized nutrition
  • randomized controlled trial
  • weight
  • BODY-MASS INDEX
  • PHYSICAL-ACTIVITY
  • PERSONALIZED NUTRITION
  • OBESITY
  • INTERVENTIONS
  • INTERNET
  • ADULTS
  • WEB
  • TECHNOLOGY

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