Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome?

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Abstract

Background and Objectives: The aim of this study was to evaluate the value of adding fetal growth velocity and first trimester maternal biomarkers to baseline screening, for the prediction of small-for-gestational age (SGA) and adverse neonatal outcomes. Method: A retrospective cohort study was conducted of singleton pregnancies in the Maastricht University Medical Centre between 2012 and 2016. The biomarkers PAPP-A, beta-hCG, PlGF, and sFlt-1 were measured at 11-13 weeks of gestational age (GA) and two fetal growth scans were performed (18-22 and 30-34 weeks of GA). Differences in biomarkers and growth velocities were compared between appropriate-for-gestational age (AGA; birth weight percentile 10-90) and SGA (birth weight percentile

Original languageEnglish
Pages (from-to)274-284
Number of pages11
JournalFetal Diagnosis and Therapy
Volume46
Issue number4
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Biochemical markers
  • Fetal biometry
  • Fetal growth restriction
  • Placenta
  • UTERINE ARTERY DOPPLER
  • PLASMA-PROTEIN-A
  • ANGIOGENIC FACTORS
  • TYROSINE KINASE-1
  • SPIRAL ARTERIES
  • EARLY-PREGNANCY
  • 3RD TRIMESTER
  • PREECLAMPSIA
  • RESTRICTION
  • RISK

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