Can dim light melatonin onset be predicted by the timing of sleep in patients with possible circadian sleep-wake rhythm disorders?

Henry Keijzer*, Karen Spruyt, Marcel G. Smits, Antoon de Geest, Leopold M. G. Curfs

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Dim Light Melatonin Onset (DLMO) is a reliable marker of the endogenous circadian rhythm. To determine if sleep timing can predict DLMO, we investigated the relationship between sleep timing and DLMO in patients in various circadian sleep-wake rhythm disorders (CSWRDs), ages and genders. We found that correlations were only moderate between DLMO and sleep-onset in the complete data-set, but they increased in patients with delayed sleep-wake phase disorder (DSWPD), DSWPD patients with a regular sleep pattern and patients with advanced sleep-wake phase disorder (ASWPD); the levels of correlation were r=0.542, 0.657, 0.728 and 0.814, respectively. In DSWPD patients with a regular sleep pattern, mid-sleep strongly correlated (r=0.839) with DLMO. Correlation in other CSRWDs was not significant. DLMO, sleep-onset and age were most discriminated factors between the various CSRWDs. Estimation of DLMO is only possible in patients with ASWPD and in DSWPD patients with a regular sleep pattern.

Original languageEnglish
Pages (from-to)557-566
Number of pages10
JournalBiological Rhythm Research
Volume48
Issue number4
DOIs
Publication statusPublished - 2017

Keywords

  • DLMO
  • melatonin
  • sleep-onset
  • CRSWD
  • data mining
  • SALIVARY MELATONIN
  • SEX-DIFFERENCES
  • PHASE SYNDROME
  • VALIDATION
  • SCHEDULES
  • PACEMAKER
  • PLASMA
  • MARKER
  • PERIOD

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