Calorie Restriction and Aging in Humans

E.W. Flanagan, J. Most, J.T. Mey, L.M. Redman*, P.J. Stover, R. Balling

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Web of Science)

Abstract

Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase life span by 1-5 years with an improvement in health span and quality of life. CR moderates intrinsic processes of aging through cellular and metabolic adaptations and reducing risk for the development of many cardiometabolic diseases. Yet, implementation of CR may require unique considerations for the elderly and other specific populations. The objectives of this review are to summarize the evidence for CR to modify primary and secondary aging; present caveats for implementation in special populations; describe newer, alternative approaches that have comparative effectiveness and fewer deleterious effects; and provide thoughts on the future of this important field of study.
Original languageEnglish
Pages (from-to)105-133
Number of pages29
JournalAnnual Review of Nutrition
Volume40
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • african-american
  • aging
  • body-fat distribution
  • bone-mineral density
  • calerie
  • calorie restriction
  • dietary restriction
  • energy-expenditure
  • glucose-tolerance
  • induced weight-loss
  • intermittent fasting
  • metabolic adaptation
  • metabolic-rate
  • randomized controlled-trial
  • skeletal-muscle mass
  • BONE-MINERAL DENSITY
  • BODY-FAT DISTRIBUTION
  • CALERIE
  • RANDOMIZED CONTROLLED-TRIAL
  • AFRICAN-AMERICAN
  • ENERGY-EXPENDITURE
  • INDUCED WEIGHT-LOSS
  • METABOLIC-RATE
  • SKELETAL-MUSCLE MASS
  • DIETARY RESTRICTION
  • GLUCOSE-TOLERANCE

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