Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health

Sai Sahana Sundararaman, Emiel P. C. van der Vorst*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Web of Science)

Abstract

The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, skin, adipose tissue, the gut, the nervous system, and the cardiovascular system. The receptor, as its name implies is involved in sensing calcium fluctuations in the extracellular matrix of cells, thereby having a major impact on the mineral homeostasis in humans. Besides calcium ions, the receptor is also activated by other di- and tri-valent cations, polypeptides, polyamines, antibiotics, calcilytics and calcimimetics, which upon binding induce intracellular signaling pathways. Recent studies have demonstrated that CaSR influences a wide variety of cells and processes that are involved in inflammation, the cardiovascular system, such as vascular calcification, atherosclerosis, myocardial infarction, hypertension, and obesity. Therefore, in this review, the current understanding of the role that CaSR plays in inflammation and its consequences on the cardiovascular system will be highlighted.

Original languageEnglish
Article number2478
Number of pages16
JournalInternational journal of molecular sciences
Volume22
Issue number5
DOIs
Publication statusPublished - Mar 2021

Keywords

  • CaSR
  • G-protein coupled receptors
  • adipose tissue
  • atherosclerosis
  • calcium-sensing receptor
  • cardiovascular disorders
  • hypertension
  • inflammation
  • myocardial ischemia
  • vascular calcification
  • ACTIVATION
  • RAT
  • EXTRACELLULAR CA2+-SENSING RECEPTORS
  • NPS 2143
  • CA2+
  • NITRIC-OXIDE PRODUCTION
  • PATHWAY
  • MOUSE MODEL
  • CHANNELS
  • EXPRESSION

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