TY - JOUR
T1 - Calcium Phosphates and Angiogenesis: Implications and Advances for Bone Regeneration
AU - Malhotra, Angad
AU - Habibovic, Pamela
PY - 2016/12
Y1 - 2016/12
N2 - Calcium phosphates (CaPs) are among the most utilized synthetic biomaterials for bone regeneration, largely owing to their established osteoconductive and osteoinductive properties. While angiogenesis is a crucial prerequisite to bone formation, research and applications for CaPs have not appreciated its crucial role. This review discusses how CaPs influence angiogenesis, and highlights promising strategies that address this topic. The objective is to draw attention to the gap in the literature and to highlight the importance of angiogenesis in CaP research, development, and use.
AB - Calcium phosphates (CaPs) are among the most utilized synthetic biomaterials for bone regeneration, largely owing to their established osteoconductive and osteoinductive properties. While angiogenesis is a crucial prerequisite to bone formation, research and applications for CaPs have not appreciated its crucial role. This review discusses how CaPs influence angiogenesis, and highlights promising strategies that address this topic. The objective is to draw attention to the gap in the literature and to highlight the importance of angiogenesis in CaP research, development, and use.
U2 - 10.1016/j.tibtech.2016.07.005
DO - 10.1016/j.tibtech.2016.07.005
M3 - Article
C2 - 27481474
SN - 0167-7799
VL - 34
SP - 983
EP - 992
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 12
ER -