Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik; Xia Yang; Tokio Mimura; Zeinab Tahmasebi Birgani; Pamela Habibovic; Kiyoshi Itatani; John A. Jansen; Jons Hilborn; Dmitri Ossipov; Antonios G. Mikos; Sander C. G. Leeuwenburgh

doi:10.1002/mabi.201300117

Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik
, Xia Yang
, Tokio Mimura
, Zeinab Tahmasebi Birgani
, Pamela Habibovic
, Kiyoshi Itatani
, John A. Jansen
, Jons Hilborn
, Dmitri Ossipov
, Antonios G. Mikos
, Sander C. G. Leeuwenburgh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	1308-1313
Number of pages	6
Journal	Macromolecular Bioscience
Volume	13
Issue number	10
DOIs	https://doi.org/10.1002/mabi.201300117
Publication status	Published - Oct 2013
Externally published	Yes

Keywords

SURFACE MODIFICATION
POLYMER NETWORKS
NANOPARTICLES
METALLOPOLYMERS
IONS

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10.1002/mabi.201300117

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title = "Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels",

abstract = "This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.{\textcopyright} 2013 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

keywords = "SURFACE MODIFICATION, POLYMER NETWORKS, NANOPARTICLES, METALLOPOLYMERS, IONS",

author = "Nejadnik, \{M. Reza\} and Xia Yang and Tokio Mimura and Birgani, \{Zeinab Tahmasebi\} and Pamela Habibovic and Kiyoshi Itatani and Jansen, \{John A.\} and Jons Hilborn and Dmitri Ossipov and Mikos, \{Antonios G.\} and Leeuwenburgh, \{Sander C. G.\}",

year = "2013",

month = oct,

doi = "10.1002/mabi.201300117",

language = "English",

volume = "13",

pages = "1308--1313",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "10",

}

TY - JOUR

T1 - Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

AU - Nejadnik, M. Reza

AU - Yang, Xia

AU - Mimura, Tokio

AU - Birgani, Zeinab Tahmasebi

AU - Habibovic, Pamela

AU - Itatani, Kiyoshi

AU - Jansen, John A.

AU - Hilborn, Jons

AU - Ossipov, Dmitri

AU - Mikos, Antonios G.

AU - Leeuwenburgh, Sander C. G.

PY - 2013/10

Y1 - 2013/10

N2 - This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - SURFACE MODIFICATION

KW - POLYMER NETWORKS

KW - NANOPARTICLES

KW - METALLOPOLYMERS

KW - IONS

U2 - 10.1002/mabi.201300117

DO - 10.1002/mabi.201300117

M3 - Article

SN - 1616-5187

VL - 13

SP - 1308

EP - 1313

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 10

ER -

Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

Abstract

Keywords

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