Caging the dragon: Research approach to COVID-19-related thrombosis

Marieke J. H. A. Kruip*, Suzanne C. Cannegieter, Hugo ten Cate, Eric C. M. van Gorp, Nicole P. Juffermans, Frederikus A. Klok, Coen Maas, Anton Vonk-Noordegraaf, Dutch & COVID Thrombosis Coalition study group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

The incidence of venous thrombosis, mostly pulmonary embolism (PE), ranging from local immunothrombosis to central emboli, but also deep vein thrombosis (DVT) in people with coronavirus disease 2019 (COVID-19) is reported to be remarkably high. The relevance of better understanding, predicting, treating, and preventing COVID-19-associated venous thrombosis meets broad support, as can be concluded from the high number of research, review, and guideline papers that have been published on this topic. The Dutch COVID & Thrombosis Coalition (DCTC) is a multidisciplinary team involving a large number of Dutch experts in the broad area of venous thrombosis and hemostasis research, combined with experts on virology, critically ill patients, pulmonary diseases, and community medicine, across all university hospitals and many community hospitals in the Netherlands. Within the consortium, clinical data of at least 5000 admitted COVID-19-infected individuals are available, including substantial collections of biobanked materials in an estimated 3000 people. In addition to considerable experience in preclinical and clinical thrombosis research, the consortium embeds virology-hemostasis research models within unique biosafety facilities to address fundamental questions on the interaction of virus with epithelial and vascular cells, in relation to the coagulation and inflammatory system. The DCTC has initiated a comprehensive research program to answer many of the current questions on the pathophysiology and best anticoagulant treatment of COVID-19-associated thrombotic complications. The research program was funded by grants of the Netherlands Thrombosis Foundation and the Netherlands Organization for Health Research and Development. Here, we summarize the design and main aims of the research program.

Original languageEnglish
Pages (from-to)278-291
Number of pages14
JournalResearch and practice in thrombosis and haemostasis
Volume5
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • COVID-19
  • anticoagulants
  • pulmonary embolism
  • severe acute respiratory syndrome coronavirus 2
  • thrombosis
  • venous thrombosis
  • ACTIVATED PROTEIN-C
  • INFLUENZA
  • DEEP-VEIN THROMBOSIS
  • RISK
  • ARTERIAL
  • VENOUS THROMBOEMBOLISM
  • PULMONARY-EMBOLISM
  • COAGULATION
  • COMPLICATIONS
  • QUALITY-OF-LIFE

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