Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.

INIS

• 3,7-dimethylxanthine 14%
• adp 100%
• antioxidants 14%
• atp 14%
• caffeine 100%
• capacity 14%
• concentration 100%
• cytokines 14%
• demand 14%
• diseases 28%
• dna 14%
• doses 14%
• elisa 14%
• enzymes 100%
• evaluation 14%
• humans 14%
• hydrogen 28%
• inflammation 42%
• inhibition 14%
• injuries 14%
• ischemia 14%
• levels 14%
• lungs 14%
• metabolites 100%
• mitochondria 14%
• nad 28%
• necrosis 14%
• pathology 14%
• polymerases 100%
• polymers 14%
• production 28%
• ribose 100%
• strand breaks 14%
• substrates 14%
• theobromine 14%
• theophylline 14%
• xanthines 14%

Keyphrases

• 1,7-dimethylxanthine 40%
• 3-methylxanthine 10%
• A549 10%
• Activator protein-1 (AP-1) 10%
• Acute Inflammatory 10%
• Acute Inflammatory Diseases 10%
• Antioxidant Effect 10%
• Caffeine 20%
• Caffeine Metabolites 100%
• Chronic Inflammatory Diseases 20%
• Diabetes 10%
• DNA Double-strand Breaks 10%
• ELISA Assay 10%
• Endothelial Cells 10%
• Epithelial Cells 10%
• High Dose 10%
• Hydrogen Peroxide 20%
• Inflammatory Cytokines 10%
• Inflammatory Pathologies 10%
• Inhibiting Activity 30%
• Ischemia-reperfusion Injury 10%
• Lung Epithelial 10%
• Methylxanthines 30%
• Mitochondrial ATP Production 10%
• Necrosis 10%
• Nuclear factor-κB 10%
• Nutritional Intervention 10%
• Overactivation 10%
• PARP Inhibitor (PARPi) 100%
• Pathophysiology 10%
• Physiological Concentrations 100%
• Poly(ADP-ribose) Polymers 10%
• Theobromine 10%
• Theophylline 10%
• Vascular Complications 10%
• Vascular Endothelial Cells 10%

Pharmacology, Toxicology and Pharmaceutical Science

• 1 Methylxanthine 25%
• 3 Methylxanthine 25%
• Adenosine Triphosphate 25%
• Antioxidant 25%
• Cytokine 25%
• Disease 25%
• Enzyme-Linked Immunosorbent Assay 25%
• Inflammatory Disease 25%
• Methylxanthine 50%
• Necrosis 25%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 100%
• Paraxanthine 100%
• Pathophysiology 25%
• Poly(adenosine Diphosphate Ribose) 25%
• Reperfusion Injury 25%
• Theobromine 25%
• Theophylline 25%