C-(4-[18F]fluorophenyl)-N-phenyl nitrone: A novel 18F-labeled building block for metal free [3+2]cycloaddition

B.D. Zlatopolskiy, R. Kandler, F.M. Mottaghy, B. Neumaier

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Radiofluorination via [3+2]-nitrone-alkene cycloaddition was studied using the model reaction between (18)F-labeled C-(4-fluorophenyl)-N-phenyl nitrone ([(18)F]1) and substituted maleimides 2a-c. [(18)F]1 was prepared in RCY of 73.6+/-5.8% and radiochemical purity of >95%. Cycloaddition of [(18)F]1 to 2a in toluene at 80 degrees C and in EtOH at 110 degrees C gave the respective isoxazolidine [(18)F]5a in >80% RCY at 10min reaction time. Reaction between [(18)F]1 and 2b, c also went smoothly to afford the respective cycloaddition products in high radiochemical yields.
Original languageEnglish
Pages (from-to)184-192
JournalApplied Radiation and Isotopes
Volume70
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012

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