Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units

Rosalie S. Linssen*, Reinout A. Bem, Berber Kapitein, Katrien Oude Rengerink, Marieke H. Otten, Bibiche den Hollander, Louis Bont, Job B. M. van Woensel, PICE Study Group, Dick van Waardenburg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Respiratory syncytial virus (RSV) bronchiolitis causes substantial morbidity and mortality in young children, but insight into the burden of RSV bronchiolitis on pediatric intensive care units (PICUs) is limited. We aimed to determine the burden of RSV bronchiolitis on the PICUs in the Netherlands. Therefore, we identified all children

Conclusion: The burden of severe RSV bronchiolitis on PICUs has increased in the Netherlands. Concomitantly, the use of non-invasive respiratory support, especially HFNC, has increased.

What is Known:

center dot RSV bronchiolitis is a major cause of childhood morbidity and mortality and may require pediatric intensive care unit admission.

center dot The field of pediatric critical care for severe bronchiolitis has changed due to increased non-invasive respiratory support options.

What is New:

center dot The burden of RSV bronchiolitis for the Dutch PICUs has increased. These data inform future strategic PICU resource planning and implementation of RSV preventive strategies.

center dot There was a significant increase in the use of high flow nasal cannula at the PICU, but the use of invasive mechanical ventilation did not decrease.

Original languageEnglish
Pages (from-to)3141-3149
Number of pages9
JournalEuropean Journal of Pediatrics
Issue number10
Publication statusPublished - Oct 2021


  • Airway management
  • Child
  • Bronchiolitis
  • High flow nasal cannula
  • Non-invasive ventilation
  • Respiratory syncytial viruses
  • Vaccination


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