Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling

Marcha Verheijen*, Yannick Schrooders, Hans Gmuender, Ramona Nudischer, Olivia Clayton, James Hynes, Steven Niederer, Henrik Cordes, Lars Kuepfer, Jos Kleinjans, Florian Caiment

*Corresponding author for this work

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Pharmacology, Toxicology and Pharmaceutical Science