Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling

Marcha Verheijen, Yannick Schrooders, Hans Gmuender, Ramona Nudischer, Olivia Clayton, James Hynes, Steven Niederer, Henrik Cordes, Lars Kuepfer, Jos Kleinjans, Florian Caiment

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)184-192
Number of pages9
JournalToxicology Letters
Volume294
DOIs
Publication statusPublished - 15 Sep 2018

Keywords

  • Doxorubicin
  • Cardiotoxicity
  • Transcriptomics
  • Physiologically-based pharmacokinetic modeling
  • 3D microtissues
  • Mitochondrial dysfunction
  • INDUCED CARDIOTOXICITY
  • CARDIOMYOPATHY
  • ADRIAMYCIN
  • CHEMOTHERAPY
  • TRANSPORT

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