Brain serotonin throughout development-for better and for worse

Research output: ThesisDoctoral ThesisInternal

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Abstract

Serotonin is a major functional modulator within the brain and affects various behaviours as well as physiological functions. Particularly, throughout development, serotonin interacts with environmental challenges to shape later-life brain function and behaviour. In the thesis “Brain serotonin throughout development-for better and for worse” the role of brain serotonin was interrogated in rodent models, using various molecular tools and behavioural screenings. Results showed that dependent on sex, early-life experiences and experimental context, brain serotonin affected socio-emotional behaviours. Furthermore, alterations in brain serotonin function in interaction with early adversity influenced RNA expression and epigenetic marks in brain regions of emotion and stress regulation.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Steinbusch, Harry, Supervisor
  • Lesch, Klaus-Peter, Supervisor
  • van den Hove, Daniel, Advisor
Award date20 Jun 2018
Place of PublicationMaastricht
Publisher
Print ISBNs9789462339408
DOIs
Publication statusPublished - 2018

Keywords

  • serotonin
  • rodent models
  • RNA expression
  • epigenetic marks

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