Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome

P.J. Visser; L. Krabbendam; F.R.J. Verhey; P.A.M. Hofman; W.M.A. Verhoeven; S. Tuinier; A. Wester; Y. W. M. M. Van Den Berg; L. F. M.  Goessens; Y. D.  Van Der Werf; J. Jolles

doi:10.1136/jnnp.67.6.774

Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome

P.J. Visser^*, L. Krabbendam, F.R.J. Verhey, P.A.M. Hofman, W.M.A. Verhoeven, S. Tuinier, A. Wester, Y. W. M. M. Van Den Berg, L. F. M. Goessens, Y. D. Van Der Werf, J. Jolles

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES To investigate the relation between anterograde amnesia and atrophy of brain structures involved in memory processing in alcoholic Korsakoff's syndrome.

METHODS The volume of brain structures involved in memory processing was measured with MRI from 13 subjects with Korsakoff's syndrome, 13 subjects with chronic alcoholism without Korsakoff's syndrome, and 13 control subjects. The brain structures analysed were the hippocampus, the parahippocampal gyrus, the mamillary bodies, the third ventricle, and the thalamus. Brain volumes were correlated with the delayed recall of a verbal learning test.

RESULTS Compared with subjects with chronic alcoholism and control subjects, subjects with Korsakoff's syndrome had a reduced volume of the hippocampus, the mamillary bodies, and the thalamus, and enlargement of the third ventricle. The impairment of delayed recall correlated with the volume of the third ventricle (r=−0.55, p=0.05) in the Korsakoff group.

CONCLUSIONS Anterograde amnesia in alcoholic Korsakoff's syndrome is associated with atrophy of the nuclei in the midline of the thalamus, but not with atrophy of the mamillary bodies, the hippocampus, or the parahippocampal gyrus.

Original language	English
Pages (from-to)	774-778
Number of pages	5
Journal	Journal of Neurology Neurosurgery and Psychiatry
Volume	67
Issue number	6
DOIs	https://doi.org/10.1136/jnnp.67.6.774
Publication status	Published - 1 Jan 1999

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Visser, P. J., Krabbendam, L., Verhey, F. R. J., Hofman, P. A. M., Verhoeven, W. M. A., Tuinier, S., Wester, A., Van Den Berg, Y. W. M. M., Goessens, L. F. M., Van Der Werf, Y. D., & Jolles, J. (1999). Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome. Journal of Neurology Neurosurgery and Psychiatry, 67(6), 774-778. https://doi.org/10.1136/jnnp.67.6.774

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title = "Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome",

abstract = "OBJECTIVES To investigate the relation between anterograde amnesia and atrophy of brain structures involved in memory processing in alcoholic Korsakoff's syndrome.METHODS The volume of brain structures involved in memory processing was measured with MRI from 13 subjects with Korsakoff's syndrome, 13 subjects with chronic alcoholism without Korsakoff's syndrome, and 13 control subjects. The brain structures analysed were the hippocampus, the parahippocampal gyrus, the mamillary bodies, the third ventricle, and the thalamus. Brain volumes were correlated with the delayed recall of a verbal learning test.RESULTS Compared with subjects with chronic alcoholism and control subjects, subjects with Korsakoff's syndrome had a reduced volume of the hippocampus, the mamillary bodies, and the thalamus, and enlargement of the third ventricle. The impairment of delayed recall correlated with the volume of the third ventricle (r=−0.55, p=0.05) in the Korsakoff group.CONCLUSIONS Anterograde amnesia in alcoholic Korsakoff's syndrome is associated with atrophy of the nuclei in the midline of the thalamus, but not with atrophy of the mamillary bodies, the hippocampus, or the parahippocampal gyrus.",

author = "P.J. Visser and L. Krabbendam and F.R.J. Verhey and P.A.M. Hofman and W.M.A. Verhoeven and S. Tuinier and A. Wester and {Van Den Berg}, {Y. W. M. M.} and Goessens, {L. F. M.} and {Van Der Werf}, {Y. D.} and J. Jolles",

year = "1999",

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doi = "10.1136/jnnp.67.6.774",

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T1 - Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome

AU - Visser, P.J.

AU - Krabbendam, L.

AU - Verhey, F.R.J.

AU - Hofman, P.A.M.

AU - Verhoeven, W.M.A.

AU - Tuinier, S.

AU - Wester, A.

AU - Van Den Berg, Y. W. M. M.

AU - Goessens, L. F. M.

AU - Van Der Werf, Y. D.

AU - Jolles, J.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - OBJECTIVES To investigate the relation between anterograde amnesia and atrophy of brain structures involved in memory processing in alcoholic Korsakoff's syndrome.METHODS The volume of brain structures involved in memory processing was measured with MRI from 13 subjects with Korsakoff's syndrome, 13 subjects with chronic alcoholism without Korsakoff's syndrome, and 13 control subjects. The brain structures analysed were the hippocampus, the parahippocampal gyrus, the mamillary bodies, the third ventricle, and the thalamus. Brain volumes were correlated with the delayed recall of a verbal learning test.RESULTS Compared with subjects with chronic alcoholism and control subjects, subjects with Korsakoff's syndrome had a reduced volume of the hippocampus, the mamillary bodies, and the thalamus, and enlargement of the third ventricle. The impairment of delayed recall correlated with the volume of the third ventricle (r=−0.55, p=0.05) in the Korsakoff group.CONCLUSIONS Anterograde amnesia in alcoholic Korsakoff's syndrome is associated with atrophy of the nuclei in the midline of the thalamus, but not with atrophy of the mamillary bodies, the hippocampus, or the parahippocampal gyrus.

AB - OBJECTIVES To investigate the relation between anterograde amnesia and atrophy of brain structures involved in memory processing in alcoholic Korsakoff's syndrome.METHODS The volume of brain structures involved in memory processing was measured with MRI from 13 subjects with Korsakoff's syndrome, 13 subjects with chronic alcoholism without Korsakoff's syndrome, and 13 control subjects. The brain structures analysed were the hippocampus, the parahippocampal gyrus, the mamillary bodies, the third ventricle, and the thalamus. Brain volumes were correlated with the delayed recall of a verbal learning test.RESULTS Compared with subjects with chronic alcoholism and control subjects, subjects with Korsakoff's syndrome had a reduced volume of the hippocampus, the mamillary bodies, and the thalamus, and enlargement of the third ventricle. The impairment of delayed recall correlated with the volume of the third ventricle (r=−0.55, p=0.05) in the Korsakoff group.CONCLUSIONS Anterograde amnesia in alcoholic Korsakoff's syndrome is associated with atrophy of the nuclei in the midline of the thalamus, but not with atrophy of the mamillary bodies, the hippocampus, or the parahippocampal gyrus.

U2 - 10.1136/jnnp.67.6.774

DO - 10.1136/jnnp.67.6.774

M3 - Article

SN - 0022-3050

VL - 67

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EP - 778

JO - Journal of Neurology Neurosurgery and Psychiatry

JF - Journal of Neurology Neurosurgery and Psychiatry

IS - 6

ER -

Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome

Abstract

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