Brain Connectome Mapping of Complex Human Traits and Their Polygenic Architecture Using Machine Learning

Luigi A. Maglanoc*, Tobias Kaufmann, Dennis van der Meer, Andre F. Marquand, Thomas Wolfers, Rune Jonassen, Eva Hilland, Ole A. Andreassen, Nils Inge Landro, Lars T. Westlye*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)


BACKGROUND: Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a noninvasive means of dissecting biological heterogeneity, yet its sensitivity, specificity, and validity in assessing individual characteristics relevant for brain function and mental health and their genetic underpinnings in clinical applications remain a challenge.

METHODS: In a machine learning approach, we predicted individual scores for educational attainment, fluid intelligence and dimensional measures of depression, anxiety, and neuroticism using functional magnetic resonance imaging-based static and dynamic temporal synchronization between large-scale brain network nodes in 10,343 healthy individuals from the UK Biobank. In addition to using age and sex to serve as our reference point, we also predicted individual polygenic scores for related phenotypes and 13 different neuroticism traits and schizophrenia.

RESULTS: Beyond high accuracy for age and sex, supporting the biological sensitivity of the connectome-based features, permutation tests revealed above chance-level prediction accuracy for trait-level educational attainment and fluid intelligence. Educational attainment and fluid intelligence were mainly negatively associated with static brain connectivity in frontal and default mode networks, whereas age showed positive correlations with a more widespread pattern. In contrast, prediction accuracy was at chance level for depression, anxiety, neuroticism, and polygenic scores across traits.

CONCLUSIONS: These novel findings provide a benchmark for future studies linking the genetic architecture of individual and mental health traits with functional magnetic resonance imaging-based brain connectomics.

Original languageEnglish
Pages (from-to)717-726
Number of pages10
JournalBiological Psychiatry
Issue number8
Publication statusPublished - 15 Apr 2020


  • Brain networks
  • fMRI
  • Functional connectivity
  • Human traits
  • Machine learning
  • Polygenic scores
  • RISK
  • AGE

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