TY - JOUR
T1 - Bone microarchitecture and strength assessed by HRpQCT in individuals with type 2 diabetes and prediabetes
T2 - the Maastricht study
AU - Van Hulten, Veerle
AU - Sarodnik, Cindy
AU - Driessen, Johanna H. M.
AU - Viggers, Rikke
AU - Rasmussen, Nicklas H.
AU - Geusens, Piet P. M. M.
AU - Schaper, Nicolaas
AU - Schram, Miranda T.
AU - De Galan, Bastiaan E.
AU - Koster, Annemarie
AU - Bours, Sandrine P. G.
AU - Vestergaard, Peter
AU - Stehouwer, Coen D. A.
AU - van den Bergh, Joop P.
PY - 2024/9
Y1 - 2024/9
N2 - Type 2 diabetes (T2D) is a prevalent disease and has been associated with an increased fracture risk despite normal or even higher areal BMD. The aim of this study was to estimate the association between glucose metabolism status (GMS) and measurements of glycemic control with HRpQCT parameters of bone microarchitecture and strength. Participants of the Maastricht study who underwent an HRpQCT scan at the distal radius and tibia were included. GMS was determined by use of an oral glucose tolerance test and grouped into a normal glucose metabolism (NGM), prediabetes, or T2D. Linear regression models were used, stratified by sex with multiple adjustments. This study incorporated cross-sectional data from 1400 (796 [56.9%] NGM, 228 [16.3%] prediabetes, and 376 [26.9%] T2D) men and 1415 (1014 [71.7%] NGM, 211 [14.9%] prediabetes, and 190 [13.4%] T2D) women. The mean age was 59.8 +/- 8.6 and 57.6 +/- 9.0 yr for men and women, respectively. After adjustment, T2D was associated with a higher total BMD measured by HRpQCT and cortical thickness, and a smaller total and trabecular area in men and women compared with NGM. In women, T2D was additionally associated with a higher stiffness and failure load at the radius. Results were more pronounced at the distal radius than at the distal tibia. To conclude, these findings suggest that in this cohort of Maastricht study participants, total and trabecular bone area are smaller, but bone microarchitecture, density, and bone strength assessed by HRpQCT are not impaired in individuals with T2D.
AB - Type 2 diabetes (T2D) is a prevalent disease and has been associated with an increased fracture risk despite normal or even higher areal BMD. The aim of this study was to estimate the association between glucose metabolism status (GMS) and measurements of glycemic control with HRpQCT parameters of bone microarchitecture and strength. Participants of the Maastricht study who underwent an HRpQCT scan at the distal radius and tibia were included. GMS was determined by use of an oral glucose tolerance test and grouped into a normal glucose metabolism (NGM), prediabetes, or T2D. Linear regression models were used, stratified by sex with multiple adjustments. This study incorporated cross-sectional data from 1400 (796 [56.9%] NGM, 228 [16.3%] prediabetes, and 376 [26.9%] T2D) men and 1415 (1014 [71.7%] NGM, 211 [14.9%] prediabetes, and 190 [13.4%] T2D) women. The mean age was 59.8 +/- 8.6 and 57.6 +/- 9.0 yr for men and women, respectively. After adjustment, T2D was associated with a higher total BMD measured by HRpQCT and cortical thickness, and a smaller total and trabecular area in men and women compared with NGM. In women, T2D was additionally associated with a higher stiffness and failure load at the radius. Results were more pronounced at the distal radius than at the distal tibia. To conclude, these findings suggest that in this cohort of Maastricht study participants, total and trabecular bone area are smaller, but bone microarchitecture, density, and bone strength assessed by HRpQCT are not impaired in individuals with T2D.
KW - type 2 diabetes
KW - HRpQCT
KW - bone
KW - fracture
KW - bone microarchitecture
KW - IN-VIVO ASSESSMENT
KW - NONENZYMATIC GLYCATION
KW - MINERAL DENSITY
KW - DISTAL RADIUS
KW - WOMEN
KW - QUALITY
KW - RISK
KW - ASSOCIATION
KW - FRACTURES
KW - MEN
U2 - 10.1093/jbmrpl/ziae086
DO - 10.1093/jbmrpl/ziae086
M3 - Article
SN - 2473-4039
VL - 8
JO - JBMR plus
JF - JBMR plus
IS - 9
M1 - ziae086
ER -