Bone induction of TiO<inf>2</inf> and Al<inf>2</inf>O<inf>3</inf> ceramic

Haitao Peng; Hong Li; Guoyu Lv; Joost D. De Bruijn; Yonggang Yan; Huipin Yuan

doi:10.3969/j.issn.1001-9731.2017.01.010

Bone induction of TiO<inf>2</inf> and Al<inf>2</inf>O<inf>3</inf> ceramic

Haitao Peng, Hong Li, Guoyu Lv, Joost D. De Bruijn, Yonggang Yan, Huipin Yuan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic

Abstract

Protein absorption, release of calcium and phosphate ions, surface calcification are the possible material mechanisms of calcium phosphate-induced ectopic bone formation. We studied the bone induction of non-microporus hydroxyapatite ceramic (HA-S), microporous HA (HA-R), microporous bioinert ceramics (TiO2 ceramic; Al2O3 ceramic; both incapable to release Ca/P ions and to get surface calcification). It was found that protein adsorption was material-specific. With almost no absorption of rhBMP-2, mirocporous TiO2 ceramic and Al2O3 ceramic induced bone formation. The results indicate that release of calcium and phosphate ions, surface calcification do not play a key role in osteoinduction, and surface microstructure induces bone formation may not be through protein adsorption.

Original language	English
Journal	Gongneng Cailiao/Journal of Functional Materials
Volume	48
Issue number	1
DOIs	https://doi.org/10.3969/j.issn.1001-9731.2017.01.010
Publication status	Published - 30 Jan 2017

Keywords

Al O ceramic 2 3
Bone induction
Surface micropore
TiO ceramic 2

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title = "Bone induction of TiO2 and Al2O3 ceramic",

abstract = "Protein absorption, release of calcium and phosphate ions, surface calcification are the possible material mechanisms of calcium phosphate-induced ectopic bone formation. We studied the bone induction of non-microporus hydroxyapatite ceramic (HA-S), microporous HA (HA-R), microporous bioinert ceramics (TiO2 ceramic; Al2O3 ceramic; both incapable to release Ca/P ions and to get surface calcification). It was found that protein adsorption was material-specific. With almost no absorption of rhBMP-2, mirocporous TiO2 ceramic and Al2O3 ceramic induced bone formation. The results indicate that release of calcium and phosphate ions, surface calcification do not play a key role in osteoinduction, and surface microstructure induces bone formation may not be through protein adsorption.",

keywords = "Al O ceramic 2 3, Bone induction, Surface micropore, TiO ceramic 2",

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TY - JOUR

T1 - Bone induction of TiO2 and Al2O3 ceramic

AU - Peng, Haitao

AU - Li, Hong

AU - Lv, Guoyu

AU - De Bruijn, Joost D.

AU - Yan, Yonggang

AU - Yuan, Huipin

PY - 2017/1/30

Y1 - 2017/1/30

N2 - Protein absorption, release of calcium and phosphate ions, surface calcification are the possible material mechanisms of calcium phosphate-induced ectopic bone formation. We studied the bone induction of non-microporus hydroxyapatite ceramic (HA-S), microporous HA (HA-R), microporous bioinert ceramics (TiO2 ceramic; Al2O3 ceramic; both incapable to release Ca/P ions and to get surface calcification). It was found that protein adsorption was material-specific. With almost no absorption of rhBMP-2, mirocporous TiO2 ceramic and Al2O3 ceramic induced bone formation. The results indicate that release of calcium and phosphate ions, surface calcification do not play a key role in osteoinduction, and surface microstructure induces bone formation may not be through protein adsorption.

AB - Protein absorption, release of calcium and phosphate ions, surface calcification are the possible material mechanisms of calcium phosphate-induced ectopic bone formation. We studied the bone induction of non-microporus hydroxyapatite ceramic (HA-S), microporous HA (HA-R), microporous bioinert ceramics (TiO2 ceramic; Al2O3 ceramic; both incapable to release Ca/P ions and to get surface calcification). It was found that protein adsorption was material-specific. With almost no absorption of rhBMP-2, mirocporous TiO2 ceramic and Al2O3 ceramic induced bone formation. The results indicate that release of calcium and phosphate ions, surface calcification do not play a key role in osteoinduction, and surface microstructure induces bone formation may not be through protein adsorption.

KW - Al O ceramic 2 3

KW - Bone induction

KW - Surface micropore

KW - TiO ceramic 2

U2 - 10.3969/j.issn.1001-9731.2017.01.010

DO - 10.3969/j.issn.1001-9731.2017.01.010

M3 - Article

SN - 1001-9731

VL - 48

JO - Gongneng Cailiao/Journal of Functional Materials

JF - Gongneng Cailiao/Journal of Functional Materials

IS - 1

ER -

Bone induction of TiO<inf>2</inf> and Al<inf>2</inf>O<inf>3</inf> ceramic

Abstract

Keywords

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