Bone disease during chronic antiepileptic drug therapy: General versus specific risk factors

Kim Beerhorst; Sylvie J. M. van der Kruijs; Pauline Verschuure; I. Y. (Francis) Tan; Albert P. Aldenkamp

doi:10.1016/j.jns.2013.05.005

Bone disease during chronic antiepileptic drug therapy: General versus specific risk factors

Kim Beerhorst, Sylvie J. M. van der Kruijs^*, Pauline Verschuure, I. Y. (Francis) Tan, Albert P. Aldenkamp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Web of Science)

Abstract

An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.

Original language	English
Pages (from-to)	19-25
Journal	Journal of the Neurological Sciences
Volume	331
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2013.05.005
Publication status	Published - 15 Aug 2013

Keywords

Anticonvulsant
Epilepsy
Bone disease
Bone mineral density
Fracture risk
Rickets
Osteopenia
Osteoporosis

Access to Document

10.1016/j.jns.2013.05.005

Cite this

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abstract = "An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed. ",

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AU - Aldenkamp, Albert P.

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KW - Fracture risk

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KW - Osteopenia

KW - Osteoporosis

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