Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer

Kim M. Smits*, Leo J. Schouten, Eszter Hudak, Bas Verhage, Boukje A. C. Van Dijk, Christina A. Hulsbergen-van de Kaa, R. Alexandra (Sandra) Goldbohm, Egbert Oosterwijk, Piet A. Van Den Brandt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)


PURPOSE: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC) A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons METHODS: After 11 3 years of follow-up, 337 incident RCC cases were identified, 185 cc-RCC cases were included for analyses RESULTS: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m(2) hazard ratio [HR] = 1 09, 95% confidence interval [CI] 1 02-1 16 and HR = 1 08, 95%CI 1 01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m(2). HR = 1.09, 95% CI 1 03-1.16) In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m(2) HR = 1.10, 95% CI 1 03-1 19) CONCLUSION: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations Ann Epidemiol 2010, 20 401-404.
Original languageEnglish
Pages (from-to)401-404
JournalAnnals of Epidemiology
Issue number5
Publication statusPublished - May 2010


  • Body Mass Index
  • Clear-cell Renal Cancer
  • VHL Mutations

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