TY - JOUR
T1 - Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer
AU - Smits, Kim M.
AU - Schouten, Leo J.
AU - Hudak, Eszter
AU - Verhage, Bas
AU - Van Dijk, Boukje A. C.
AU - Hulsbergen-van de Kaa, Christina A.
AU - Goldbohm, R. Alexandra (Sandra)
AU - Oosterwijk, Egbert
AU - Van Den Brandt, Piet A.
PY - 2010/5
Y1 - 2010/5
N2 - PURPOSE: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC) A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons METHODS: After 11 3 years of follow-up, 337 incident RCC cases were identified, 185 cc-RCC cases were included for analyses RESULTS: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m(2) hazard ratio [HR] = 1 09, 95% confidence interval [CI] 1 02-1 16 and HR = 1 08, 95%CI 1 01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m(2). HR = 1.09, 95% CI 1 03-1.16) In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m(2) HR = 1.10, 95% CI 1 03-1 19) CONCLUSION: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations Ann Epidemiol 2010, 20 401-404.
AB - PURPOSE: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC) A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons METHODS: After 11 3 years of follow-up, 337 incident RCC cases were identified, 185 cc-RCC cases were included for analyses RESULTS: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m(2) hazard ratio [HR] = 1 09, 95% confidence interval [CI] 1 02-1 16 and HR = 1 08, 95%CI 1 01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m(2). HR = 1.09, 95% CI 1 03-1.16) In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m(2) HR = 1.10, 95% CI 1 03-1 19) CONCLUSION: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations Ann Epidemiol 2010, 20 401-404.
KW - Body Mass Index
KW - Clear-cell Renal Cancer
KW - VHL Mutations
U2 - 10.1016/j.annepidem.2010.01.010
DO - 10.1016/j.annepidem.2010.01.010
M3 - Article
C2 - 20382342
SN - 1047-2797
VL - 20
SP - 401
EP - 404
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 5
ER -