@article{3e905714cf9e429da5049d689f9221ea,
title = "Blood Metabolites Associate with Prognosis in Endometrial Cancer",
abstract = "Endometrial cancer has a high prevalence among post-menopausal women in developed countries. We aimed to explore whether certain metabolic patterns could be related to the characteristics of aggressive disease and poorer survival among endometrial cancer patients in Western Norway. Patients with endometrial cancer with short survival (n = 20) were matched according to FIGO (International Federation of Gynecology and Obstetrics, 2009 criteria) stage, histology, and grade, with patients with long survival (n = 20). Plasma metabolites were measured on a multiplex system including 183 metabolites, which were subsequently determined using liquid chromatography-mass spectrometry. Partial least square discriminant analysis, together with hierarchical clustering, was used to identify patterns which distinguished short from long survival. A proposed signature of metabolites related to survival was suggested, and a multivariate receiver operating characteristic (ROC) analysis yielded an area under the curve (AUC) of 0.820-0.965 (p",
keywords = "metabolomics, biomarker, endometrial cancer, VISCERAL ADIPOSE-TISSUE, NEOADJUVANT CHEMOTHERAPY, METABOLOMIC SIGNATURE, BIOMARKERS, METHIONINE, CELLS, SERUM, GENE",
author = "Elin Strand and Tangen, {Ingvild L.} and Fasmer, {Kristine E.} and Havjin Jacob and Halle, {Mari K.} and Hoivik, {Erling A.} and Bert Delvoux and Jone Trovik and Haldorsen, {Ingfrid S.} and Andrea Romano and Camilla Krakstad",
note = "Funding Information: Acknowledgments: We are grateful to Kadri Madisoo, Ellen Valen, Ann-Helen Pridesis, and Karlijn Cornel for technical assistance. The Genomics Core Facility (GCF) at the University of Bergen, which is a part of the NorSeq consortium, provided services on high throughput sequencing; GCF is supported in part by major grants from the Research Council of Norway (grant no. 245979/F50) and Bergen Research Foundation (BFS) (grant no. BFS2016-genom). This work was also partly supported by the Centre of Cancer Biomarkers, a Centre of Excellence funded by the Research Council of Norway{\textquoteright}s funding scheme, project number 223250. Funding Information: Funding: This research was funded by Helse Vest, the University of Bergen, the Norwegian Cancer Society, the Research Council of Norway, Bergen Research Foundation granted to C.K., and the Dutch Cancer Society ({\textquoteleft}KWF Kankerbestrijding{\textquoteright}: www.kwf.nl), contract number UM-13-5782 granted to A.R. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = dec,
doi = "10.3390/metabo9120302",
language = "English",
volume = "9",
journal = "Metabolites",
issn = "2218-1989",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}