Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Aristotelis Chatziioannou, Panagiotis Georgiadis, Dennie G. Hebels, Irene Liampa, Ioannis Valavanis, Ingvar A. Bergdahl, Anders Johansson, Domenico Palli, Marc Chadeau-Hyam, Alexandros P. Siskos, Hector Keun, Maria Botsivali, Theo M. C. M. de Kok, Almudena Espin Perez, Jos C. S. Kleinjans, Paolo Vineis, Soterios A. Kyrtopoulos*, EnviroGenomarkers Project Consorti

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 haem oxygenase 1) and BCL2L1 (BCL2- like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.

Original languageEnglish
Article number42870
Number of pages13
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 22 Feb 2017

Keywords

  • OBSTRUCTIVE PULMONARY-DISEASE
  • CORONARY-HEART-DISEASE
  • SEX-DIFFERENCES
  • LUNG-CANCER
  • PLATELET ACTIVATION
  • GENE-EXPRESSION
  • MYOCARDIAL-INFARCTION
  • CIGARETTE-SMOKING
  • HEME OXYGENASE-1
  • RISK-FACTOR

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