Abstract
The two bradykinin receptors B1R and B2R are central components of the kallikrein-kinin system with different expression kinetics and binding characteristics. Activation of these receptors by kinins triggers inflammatory responses in the target organ and in most situations enhances tissue damage. We could recently show that blocking of B1R, but not B2R, protects from cortical cryolesion by reducing inflammation and edema formation. In the present study, we investigated the role of B1R and B2R in a closed head model of focal traumatic brain injury (TBI; weight drop). Increased expression of B1R in the injured hemispheres of wild-type mice was restricted to the later stages after brain trauma, i.e. day 7 (P0.05). Mice lacking the B1R, but not the B2R, showed less functional deficits on day 3 (P
Original language | English |
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Pages (from-to) | 1747-1756 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 32 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2012 |
Keywords
- astrocytes
- beta-APP
- closed head injury
- kinin receptors
- R-715
- TNF-alpha