Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

Tanja Vajen; Rory R. Koenen; Isabella Werner; Mareike Staudt; Delia Projahn; Adelina Curaj; Tolga Taha Sonmez; Sakine Simsekyilmaz; David Schumacher; Julia Mollmann; Tilman M. Hackeng; Philipp von Hundelshausen; Christian Weber; Elisa A. Liehn

doi:10.1038/s41598-018-29026-0

Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

Tanja Vajen, Rory R. Koenen^*, Isabella Werner, Mareike Staudt, Delia Projahn, Adelina Curaj, Tolga Taha Sonmez, Sakine Simsekyilmaz, David Schumacher, Julia Mollmann, Tilman M. Hackeng, Philipp von Hundelshausen, Christian Weber, Elisa A. Liehn

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

29 Citations (Web of Science)

Original language	English
Article number	10647
Number of pages	11
Journal	Scientific Reports
Volume	8
DOIs	https://doi.org/10.1038/s41598-018-29026-0
Publication status	Published - 13 Jul 2018

Keywords

ISCHEMIA/REPERFUSION INJURY
PLATELET CHEMOKINES
NEOINTIMA FORMATION
MONOCYTE SUBSETS
DEFICIENT MICE
ATHEROSCLEROSIS
CCR5
RANTES
PLATELET-FACTOR-4
INFECTION

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10.1038/s41598-018-29026-0

https://doi.org/10.1038/s41598-018-29026-0

Cite this

Vajen, T., Koenen, R. R., Werner, I., Staudt, M., Projahn, D., Curaj, A., Sonmez, T. T., Simsekyilmaz, S., Schumacher, D., Mollmann, J., Hackeng, T. M., von Hundelshausen, P., Weber, C., & Liehn, E. A. (2018). Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis. Scientific Reports, 8, [10647]. https://doi.org/10.1038/s41598-018-29026-0

Vajen, Tanja ; Koenen, Rory R. ; Werner, Isabella ; Staudt, Mareike ; Projahn, Delia ; Curaj, Adelina ; Sonmez, Tolga Taha ; Simsekyilmaz, Sakine ; Schumacher, David ; Mollmann, Julia ; Hackeng, Tilman M. ; von Hundelshausen, Philipp ; Weber, Christian ; Liehn, Elisa A. / Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis. In: Scientific Reports. 2018 ; Vol. 8.

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title = "Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis",

keywords = "ISCHEMIA/REPERFUSION INJURY, PLATELET CHEMOKINES, NEOINTIMA FORMATION, MONOCYTE SUBSETS, DEFICIENT MICE, ATHEROSCLEROSIS, CCR5, RANTES, PLATELET-FACTOR-4, INFECTION",

author = "Tanja Vajen and Koenen, {Rory R.} and Isabella Werner and Mareike Staudt and Delia Projahn and Adelina Curaj and Sonmez, {Tolga Taha} and Sakine Simsekyilmaz and David Schumacher and Julia Mollmann and Hackeng, {Tilman M.} and {von Hundelshausen}, Philipp and Christian Weber and Liehn, {Elisa A.}",

year = "2018",

month = jul,

day = "13",

doi = "10.1038/s41598-018-29026-0",

language = "English",

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Vajen, T, Koenen, RR, Werner, I, Staudt, M, Projahn, D, Curaj, A, Sonmez, TT, Simsekyilmaz, S, Schumacher, D, Mollmann, J, Hackeng, TM, von Hundelshausen, P, Weber, C & Liehn, EA 2018, 'Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis', Scientific Reports, vol. 8, 10647. https://doi.org/10.1038/s41598-018-29026-0

Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis. / Vajen, Tanja; Koenen, Rory R.; Werner, Isabella; Staudt, Mareike; Projahn, Delia; Curaj, Adelina; Sonmez, Tolga Taha; Simsekyilmaz, Sakine; Schumacher, David; Mollmann, Julia; Hackeng, Tilman M.; von Hundelshausen, Philipp; Weber, Christian; Liehn, Elisa A.

In: Scientific Reports, Vol. 8, 10647, 13.07.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

AU - Vajen, Tanja

AU - Koenen, Rory R.

AU - Werner, Isabella

AU - Staudt, Mareike

AU - Projahn, Delia

AU - Curaj, Adelina

AU - Sonmez, Tolga Taha

AU - Simsekyilmaz, Sakine

AU - Schumacher, David

AU - Mollmann, Julia

AU - Hackeng, Tilman M.

AU - von Hundelshausen, Philipp

AU - Weber, Christian

AU - Liehn, Elisa A.

PY - 2018/7/13

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KW - ISCHEMIA/REPERFUSION INJURY

KW - PLATELET CHEMOKINES

KW - NEOINTIMA FORMATION

KW - MONOCYTE SUBSETS

KW - DEFICIENT MICE

KW - ATHEROSCLEROSIS

KW - CCR5

KW - RANTES

KW - PLATELET-FACTOR-4

KW - INFECTION

U2 - 10.1038/s41598-018-29026-0

DO - 10.1038/s41598-018-29026-0

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10647

ER -