TY - JOUR
T1 - Bioprinting
T2 - From Tissue and Organ Development to in Vitro Models
AU - Mota, Carlos
AU - Camarero-Espinosa, Sandra
AU - Baker, Matthew B
AU - Wieringa, Paul
AU - Moroni, Lorenzo
N1 - Funding Information:
We are grateful to the Dutch Kidney Foundation (Nierstichting Nederland, grant 18OI17 – Innovation Call 2018) and to the European Research Council starting grant “Cell Hybridge” (Grant #637308) and H2020-NMP-PILOTS-2015 “FAST” (Grant #685825), under the Horizon 2020 framework program for financial support. We also acknowledge support from the Dutch Province of Limburg and from the research programme Innovation Fund Chemistry, which is partly financed by The Netherlands Organisation for Scientific Research (NWO). The authors would like to thank Rogier Trompert for the illustrations.
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/10/14
Y1 - 2020/10/14
N2 - Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments in the past years. Novel biomaterial inks used for the formation of bioinks have been developed, allowing the manufacturing of in vitro models and implants tested preclinically with a certain degree of success. Furthermore, incredible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the latest milestones where more relevant tissues or organ-like constructs with a certain degree of functionality can already be obtained. These incredible strides have been possible with a multitude of multidisciplinary teams around the world, working to make bioprinted tissues and organs more relevant and functional. Yet, there is still a long way to go until these biofabricated constructs will be able to reach the clinics. In this review, we summarize the main bioprinting activities linking them to tissue and organ development and physiology. Most bioprinting approaches focus on mimicking fully matured tissues. Future bioprinting strategies might pursue earlier developmental stages of tissues and organs. The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.
AB - Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments in the past years. Novel biomaterial inks used for the formation of bioinks have been developed, allowing the manufacturing of in vitro models and implants tested preclinically with a certain degree of success. Furthermore, incredible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the latest milestones where more relevant tissues or organ-like constructs with a certain degree of functionality can already be obtained. These incredible strides have been possible with a multitude of multidisciplinary teams around the world, working to make bioprinted tissues and organs more relevant and functional. Yet, there is still a long way to go until these biofabricated constructs will be able to reach the clinics. In this review, we summarize the main bioprinting activities linking them to tissue and organ development and physiology. Most bioprinting approaches focus on mimicking fully matured tissues. Future bioprinting strategies might pursue earlier developmental stages of tissues and organs. The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.
KW - PLURIPOTENT STEM-CELLS
KW - RAT SCIATIC-NERVE
KW - EXTRACELLULAR-MATRIX COMPONENTS
KW - MAGNETICALLY ALIGNED COLLAGEN
KW - EARLY KIDNEY DEVELOPMENT
KW - ON-A-CHIP
KW - PERIPHERAL-NERVE
KW - MECHANICAL-PROPERTIES
KW - ARTICULAR-CARTILAGE
KW - SCHWANN-CELLS
U2 - 10.1021/acs.chemrev.9b00789
DO - 10.1021/acs.chemrev.9b00789
M3 - (Systematic) Review article
C2 - 32407108
SN - 0009-2665
VL - 120
SP - 10547
EP - 10607
JO - Chemical Reviews
JF - Chemical Reviews
IS - 19
ER -