Biomimetic Cascade Strategies Towards 2-Aminoindolines From Alkaloids

Timo van Schaik; Jordy M. Saya; Eelco Ruijter; Romano V.A. Orru

doi:10.17374/targets.2022.25.256

Biomimetic Cascade Strategies Towards 2-Aminoindolines From Alkaloids

Timo van Schaik, Jordy M. Saya, Eelco Ruijter, Romano V.A. Orru^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The 2-aminoindoline scaffold is abundant in natural alkaloids with antibacterial, antitumor and anti-inflammatory activities. Synthetic organic chemists have developed various elegant strategies towards this heterocyclic core. These strategies often entail a cascading sequence, where two or more bonds are formed simultaneously. Potentially, these approaches drastically decrease the number of reaction steps required typically minimizing waste generation and energy consumption. These features are a requisite for the present development of new and accessible more greener pharmaceuticals. This review will uncover the synthetic cascade toolbox towards the 2-aminoindolines core focussing on synthetic applicability and discussing the different reaction mechanisms involved

Original language	English
Pages (from-to)	256-280
Number of pages	25
Journal	Targets in Heterocyclic Systems
Volume	25
DOIs	https://doi.org/10.17374/targets.2022.25.256
Publication status	Published - 1 Jan 2021

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abstract = "The 2-aminoindoline scaffold is abundant in natural alkaloids with antibacterial, antitumor and anti-inflammatory activities. Synthetic organic chemists have developed various elegant strategies towards this heterocyclic core. These strategies often entail a cascading sequence, where two or more bonds are formed simultaneously. Potentially, these approaches drastically decrease the number of reaction steps required typically minimizing waste generation and energy consumption. These features are a requisite for the present development of new and accessible more greener pharmaceuticals. This review will uncover the synthetic cascade toolbox towards the 2-aminoindolines core focussing on synthetic applicability and discussing the different reaction mechanisms involved",

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DO - 10.17374/targets.2022.25.256

M3 - Article

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JF - Targets in Heterocyclic Systems

ER -

Biomimetic Cascade Strategies Towards 2-Aminoindolines From Alkaloids

Abstract

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