Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study

Susana Ravassa, Tatiana Kuznetsova, Nerea Varo, Lutgarde Thijs, Christian Delles, Anna Dominiczak, Javier Diez*, Jan A. Staessen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)

Abstract

Background/objectives: The validation of effective screening tools for the identification of patients with subclinical myocardial remodelling is a major clinical need. Thus, we explored the associations of circulating biomarkers of cardiomyocyte injury and stress with subclinical cardiac remodelling and dysfunction, and with biomarkers reflecting collagen turnover. Methods: We randomly recruited 727 subjects from a general population (51.2% women; mean age 51.3 years). Measurements included echocardiographic left atrial (LA) and left ventricular (LV) structure and function, quantification of high sensitivity cardiac Troponin T (hs-cTnT), NT-proBNP, and biomarkers of collagen types I and III turnover. Results: In unadjusted and adjusted analyses, the prevalence of LA enlargement (LAE), LV hypertrophy (LVH) and LV diastolic dysfunction (LVDD) increased with higher hs-cTnT (P
Original languageEnglish
Pages (from-to)177-185
JournalInternational Journal of Cardiology
Volume185
DOIs
Publication statusPublished - 15 Apr 2015

Keywords

  • hs-cTnT
  • Left ventricular remodelling
  • Left atrial remodelling
  • Diastolic dysfunction
  • Collagen metabolism
  • NT-proBNP

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