Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study

Susana Ravassa; Tatiana Kuznetsova; Nerea Varo; Lutgarde Thijs; Christian Delles; Anna Dominiczak; Javier Diez; Jan A. Staessen

doi:10.1016/j.ijcard.2015.03.046

Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study

Susana Ravassa, Tatiana Kuznetsova, Nerea Varo, Lutgarde Thijs, Christian Delles, Anna Dominiczak, Javier Diez^*, Jan A. Staessen

^*Corresponding author for this work

Epidemiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background/objectives: The validation of effective screening tools for the identification of patients with subclinical myocardial remodelling is a major clinical need. Thus, we explored the associations of circulating biomarkers of cardiomyocyte injury and stress with subclinical cardiac remodelling and dysfunction, and with biomarkers reflecting collagen turnover. Methods: We randomly recruited 727 subjects from a general population (51.2% women; mean age 51.3 years). Measurements included echocardiographic left atrial (LA) and left ventricular (LV) structure and function, quantification of high sensitivity cardiac Troponin T (hs-cTnT), NT-proBNP, and biomarkers of collagen types I and III turnover. Results: In unadjusted and adjusted analyses, the prevalence of LA enlargement (LAE), LV hypertrophy (LVH) and LV diastolic dysfunction (LVDD) increased with higher hs-cTnT (P

Original language	English
Pages (from-to)	177-185
Journal	International Journal of Cardiology
Volume	185
DOIs	https://doi.org/10.1016/j.ijcard.2015.03.046
Publication status	Published - 15 Apr 2015

Keywords

hs-cTnT
Left ventricular remodelling
Left atrial remodelling
Diastolic dysfunction
Collagen metabolism
NT-proBNP

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10.1016/j.ijcard.2015.03.046

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title = "Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study",

abstract = "Background/objectives: The validation of effective screening tools for the identification of patients with subclinical myocardial remodelling is a major clinical need. Thus, we explored the associations of circulating biomarkers of cardiomyocyte injury and stress with subclinical cardiac remodelling and dysfunction, and with biomarkers reflecting collagen turnover. Methods: We randomly recruited 727 subjects from a general population (51.2% women; mean age 51.3 years). Measurements included echocardiographic left atrial (LA) and left ventricular (LV) structure and function, quantification of high sensitivity cardiac Troponin T (hs-cTnT), NT-proBNP, and biomarkers of collagen types I and III turnover. Results: In unadjusted and adjusted analyses, the prevalence of LA enlargement (LAE), LV hypertrophy (LVH) and LV diastolic dysfunction (LVDD) increased with higher hs-cTnT (P ",

keywords = "hs-cTnT, Left ventricular remodelling, Left atrial remodelling, Diastolic dysfunction, Collagen metabolism, NT-proBNP",

author = "Susana Ravassa and Tatiana Kuznetsova and Nerea Varo and Lutgarde Thijs and Christian Delles and Anna Dominiczak and Javier Diez and Staessen, {Jan A.}",

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T1 - Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study

AU - Ravassa, Susana

AU - Kuznetsova, Tatiana

AU - Varo, Nerea

AU - Thijs, Lutgarde

AU - Delles, Christian

AU - Dominiczak, Anna

AU - Diez, Javier

AU - Staessen, Jan A.

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Background/objectives: The validation of effective screening tools for the identification of patients with subclinical myocardial remodelling is a major clinical need. Thus, we explored the associations of circulating biomarkers of cardiomyocyte injury and stress with subclinical cardiac remodelling and dysfunction, and with biomarkers reflecting collagen turnover. Methods: We randomly recruited 727 subjects from a general population (51.2% women; mean age 51.3 years). Measurements included echocardiographic left atrial (LA) and left ventricular (LV) structure and function, quantification of high sensitivity cardiac Troponin T (hs-cTnT), NT-proBNP, and biomarkers of collagen types I and III turnover. Results: In unadjusted and adjusted analyses, the prevalence of LA enlargement (LAE), LV hypertrophy (LVH) and LV diastolic dysfunction (LVDD) increased with higher hs-cTnT (P

AB - Background/objectives: The validation of effective screening tools for the identification of patients with subclinical myocardial remodelling is a major clinical need. Thus, we explored the associations of circulating biomarkers of cardiomyocyte injury and stress with subclinical cardiac remodelling and dysfunction, and with biomarkers reflecting collagen turnover. Methods: We randomly recruited 727 subjects from a general population (51.2% women; mean age 51.3 years). Measurements included echocardiographic left atrial (LA) and left ventricular (LV) structure and function, quantification of high sensitivity cardiac Troponin T (hs-cTnT), NT-proBNP, and biomarkers of collagen types I and III turnover. Results: In unadjusted and adjusted analyses, the prevalence of LA enlargement (LAE), LV hypertrophy (LVH) and LV diastolic dysfunction (LVDD) increased with higher hs-cTnT (P

KW - hs-cTnT

KW - Left ventricular remodelling

KW - Left atrial remodelling

KW - Diastolic dysfunction

KW - Collagen metabolism

KW - NT-proBNP

U2 - 10.1016/j.ijcard.2015.03.046

DO - 10.1016/j.ijcard.2015.03.046

M3 - Article

C2 - 25796005

SN - 0167-5273

VL - 185

SP - 177

EP - 185

JO - International Journal of Cardiology

JF - International Journal of Cardiology

ER -

Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study

Abstract

Keywords

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