This thesis aims to better understand the relationships between inflammation and mood disorders. Using molecular approaches on clinical patient groups, this thesis provides further evidence for the role of immune-related pathways in the mechanism of action of lithium for mood stabilization in bipolar disorder and electroconvulsive therapy for treatment-resistant depression. It furthermore has extended the current knowledge about antidepressant effects of infliximab (an anti-inflammatory) in Crohn’s Disease. These novel insights form the next steps showing that immune-related pathways are relevant for the onset and treatment of mood disorders and have the potential to deliver important prognostic information to personalize and optimize treatment.
|Qualification||Doctor of Philosophy|
|Award date||2 Dec 2015|
|Place of Publication||Maastricht|
|Publication status||Published - 2015|
- bipolar disorder
- immune system